Study type:
Medical/biological study
(experimental study)
Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure
med./bio.
By:
Luo X, Chen M, Duan Y, Duan W, Zhang H, He Y, Yin C, Sun G, Sun X
Published in: Biomed Pharmacother 2016; 82: 640-648
In a previous study (Duan et al. 2013), the authors reported that lotus seedpod procyanidins (LSPCs) treatment prevented a magnetic field related increase in oxidation products and deficits in cognitive functions of mice, which suggested that LSPCs may have the potential to stimulate antioxidantenzyme activity and to scavenge oxygenfree radicals. First, the effect of different magnetic flux densities was investigated and male mice were divided into the following groups (n=12 each): exposure to a magnetic field of 1) 2 mT, 2) 4 mT, 3) 6 mT, 4) 8 mT, 5) 10 mT and 6) sham exposure for 7-28 days (4 h/day). Secondly, the protective effect of LSPCs was investigated. LSPC extracts were administered orally once per day 15 days prior to and during exposure. Male mice were divided into the following groups (n=12 each): 7) exposure to an 8 mT magnetic field for 28 days (4 h/day) and oral saline administration, 8) exposure and 60 mg/kg LSPCs, 9) exposure + 90 mg/kg LSPCs, 10) exposure + 120 mg/kg LSPCs, 11) sham exposure.
ventilated perspex boxes of dimensions 14 cm x 10 cm x 12 cm in a room at a controlled temperature (23°C ± 2°C)
Setup
the magnetic field was generated with a pair of Helmholtz coils (1.0 mm wire diameter, 32 cm internal diameter, 36 cm external diameter, 500 turns) placed vertically to the ground; mice were placed in the boxes in the middle of the pair of coils, but the box was not in contact with the coils; the temperature inside the ventilated perspex box was 23°C ± 0.5°C
Scientific Research Projects of Chinese Medicine Industry, China
The Priority Academic Program Development of Jiangsu Higher Education Institutions, China
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