研究のタイプ: 医学／生物学の研究 (experimental study)

[GSM変調無線周波放射はラットの6‐スルファトキシメラトニン分泌に影響しない。] med./bio.

GSM modulated radiofrequency radiation does not affect 6-sulfatoxymelatonin excretion of rats

著者: Bakos J, Kubinyi G, Sinay H, Thuroczy G
掲載誌: Bioelectromagnetics 2003; 24 (8): 531-534
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この研究は、成獣雄ウィスターラットの尿中6‐スルファトキシメラトニン（6SM)に対する900および1800MHzGSM様無線周波放射（搬送周波数218Hz）の影響を調べた。ばく露には、ギガヘルツＴＥＭセルを用いた。ばく露の放射電力密度は、900MHzは100 μW/cm2、1800MHzは20 μW/cm2で、1日2時間、14日間実施した。毎日正午にはばく露を終了し、その後翌朝8時までの尿を採集した。ばく露群、擬似ばく露対照群（各6匹）の尿の採集は、それぞれ1日交代で行った。2つの周波数で同じ実験を3回繰り返し、全部で72匹のラットを用いた。同じ周波数で実施した3回の実験の結果を統合して統計的に分析した。その結果、900、1800MHzのどちらでも、ばく露群(n=18)と擬似ばく露対照群(n=18)の6MS分泌に有意差はなかった，と報告している。

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研究目的（著者による）

To investigate the effect of a GSM radio frequency exposure on 6-sulphatoxymelatonin urinary excretion in rats.

詳細情報

Animals were exposed for 2 weeks (2 h daily) to 900 MHz (power density 100 µW/cm2) or 1800 MHz (power density 20 µW/cm2), modulated at 218 Hz. 6-sulphatoxymelatonin is the major metabolite of melatonin and could easily non-invasive determined in excreted urine.
A total of 72 animals were used in this study. Each experimental setup (i.e. 900 MHz or 1800 MHz) contained 36 animals, divided into 3 subgroups (12 animals each), and each setup was identical repeated three times consecutively. In each subgroup 6 animals were exposed or sham-exposed, respectively, and the obtained data were pooled. Thus, 18 animals were exposed or sham-exposed, respectively, in each experimental setup.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure of 2 h/day for 14 days
ばく露2: 1,800 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure of 2 h/day for 14 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 repeated daily exposure of 2 h/day for 14 days
Modulation
Modulation type pulsed
Repetition frequency 218 Hz
Additional information

Speech was not simulated in the RF signal.
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • TEMセル
  • 2 m high, 1.2 m x 1.2 m floor space
チャンバの詳細 The GTEM cell was positioned vertically, and the dominant E-field component was horizontal within the exposure area.
ばく露装置の詳細 Six freely moving rats were kept in a purely plastic cage of 40 x 30 x 10 cm which was placed over the absorbent material of the GTEM cell at a distance of 0.85 m from the septum. The RF signal was produced by a mobile test phone and a power amplifier.
Additional information The sham exposed control animals were handled just like the exposed ones, but without RF irradiation.
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 19.4 V/m mean 測定値 - ± 2.8 V/m
電力密度 100 µW/cm² mean 測定値 - at 19.4 V/m
SAR 0.012 W/g - 計算値 whole body 0.009-0.012 W/kg
Additional parameter details

Background 50 Hz MF was 0.2-0.4 µT.

測定および計算の詳細

The power was measured by an RF power meter and a spectrum analyzer. The required input power was calculated according to the dimension of the GTEM cell and the position level of the cage. A field uniformity better than 15% across the volume within the cage occupied by the exposure box was expected and confirmed by measurements made at 5-cm intervals in a horizontal plane using a single axis E-field probe and an isotropic probe (both having calibration uncertainties of 1.5 dB) connected to the field meter via an optical cable. The whole-body SAR was estimated using data for a spheroid model according to the USAF rat model (see reference article).

ばく露2

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 repeated daily exposure of 2 h/day for 14 days
Modulation
Modulation type pulsed
Repetition frequency 218 Hz
Additional information

Speech was not simulated in the RF signal.
ばく露装置
ばく露の発生源／構造
  • TEMセル
  • 2 m high, 1.2 m x 1.2 m floor space
ばく露装置の詳細 The RF signal was produced by a pulse generator, a signal generator and an amplifier.
パラメータ
測定量 値 種別 Method Mass 備考
電界強度 8.6 V/m mean 測定値 - ± 1.2 V/m
電力密度 20 µW/cm² mean 測定値 - at 8.6 V/m
SAR 0.045 W/kg - 計算値 whole body 0.022-0.045 W/kg

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

Neither exposure to 900 MHz nor to 1800 MHz revealed statistically significant changes in the nocturnal excretion of 6-sulphatoxymelatonin in rats compared to sham-exposed control groups.

研究の種別:

研究助成

関連論文