研究のタイプ: 医学／生物学の研究 (experimental study)

[ジャンガリアンハムスターのメラトニンおよび体重に対する非熱的SAR値の携帯電話電磁界の影響] med./bio.

Effects of mobile phone electromagnetic fields at nonthermal SAR values on melatonin and body weight of Djungarian hamsters (Phodopus sungorus)

著者: Lerchl A, Kruger H, Niehaus M, Streckert JR, Bitz AK, Hansen V
掲載誌: J Pineal Res 2008; 44 (3): 267-272
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この研究は、成獣雄ジャンガリアンハムスターに、３８３、900, 1800 MHz（383 MHzはTETRA変調、900 、1800 MHzは標準GSM変調）のRF-EMFばく露を1日24時間、60日間与えた。ばく露には、放射状の導波管システムを用い、ばく露レベルは公衆の全身ばく露ガイドライン値と同等とした。ばく露群(n=120）、擬似ばく露群(n=120）はブラインド化して実験した。その結果、ばく露終了後に測定した松果体および血清のメラトニンレベル、およびばく露中の10日毎に測定した精巣、脳、腎臓、肝臓の重量に、ばく露による影響は見られなかった、と報告している。

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研究目的（著者による）

This in vivo study was performed to assess the effects of chronic radio frequency electromagnetic fields exposure on hamster body weight as an indicator of metabolic changes.

詳細情報

Altogether 120 male Djungarian hamsters (3-7 months old) were sham exposed and 120 hamsters were exposed to the specific absorption rate of 80 mW/kg (limit value for the general public defined by ICNIRP).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 383 MHz
Modulation type: pulsed
ばく露時間: continuous for 60 days
  • SAR: 80 mW/kg mean (whole body) (±16%)
ばく露2: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 60 days
  • SAR: 80 mW/kg mean (whole body) (±30%)
ばく露3: 1,800 MHz
Modulation type: pulsed
ばく露時間: continuous for 60 days
  • SAR: 80 mW/kg mean (whole body) (±35%)

ばく露1

主たる特性
周波数 383 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 60 days
Modulation
Modulation type pulsed
Duty cycle 25 %
Repetition frequency 17.65 Hz
Additional information

TETRA signal with 14.167 ms burst duration
ばく露装置
ばく露の発生源／構造
チャンバの詳細 The radial waveguides [Hansen et al., 1999] were 4.5 m in diameter and 14 cm high and were terminated at their radial boundaries by metal-backed absorbers. A cone antenna mounted in the center excited only the fundamental TEM mode, resulting in a uniform field distribution in the cross-section.
ばく露装置の詳細 For each experiment, 120 animals were RF or sham exposed in two identical exposure units (blind design). Forty macrolon cages (W 16 cm x L 23 cm x H 10 cm) per unit (each housing three unrestrained animals) were arranged at a constant distance from the antenna. Ten trapezoidal openings (approx. 1 m x 0.4 m) above the cages were closed by wire mesh lids.
Sham exposure A sham exposure was conducted.
Additional information Room temperature measurements showed little difference between the exposure units (383 MHz: <0.6°C, 900 MHz: <1.2°C, 1800 MHz: <1.6°C).
パラメータ
測定量 値 種別 Method Mass 備考
SAR 80 mW/kg mean 計算値 whole body ±16%
Additional parameter details

Local SAR values (10-g averaged) were well below 2 W/kg in all simulations.

測定および計算の詳細

For SAR determination, a detailed computer model of a hamster (50 g) comprising 22 different tissue types was generated by NMR scans. The variations of the whole-body SAR with the postures and positions of the three hamsters in the cage were analysed by numerical calculations of the EMF distribution.

ばく露2

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 60 days
Modulation
Modulation type pulsed
Duty cycle 87.5 %
Additional information

typical GSM scenario of a base station signal combined with a mobile phone contribution, thus including 2.1, 8.3, 217, and 1733 Hz frequency components
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 80 mW/kg mean 計算値 whole body ±30%

ばく露3

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 60 days
Modulation
Modulation type pulsed
Duty cycle 87.5 %
Additional information

same as E2
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
チャンバの詳細 For 1800 MHz, the plate distance at the inner part of the waveguide was reduced to 7 cm to prevent higher order modes with non-uniform field distributions.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 80 mW/kg mean 計算値 whole body ±35%

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The exposure to 383 MHz resulted in a significant transient increase in body weight, while at the exposure to 900 MHz this body weight increase was more pronounced and not transient. At 1800 MHz, no effect on body weight was seen.
In all exposures (383 MHz, 900 MHz or 1800 MHz) the pineal and serum melatonin level as well as the weights of brain, liver, kidneys and testes were not affected.

研究の種別:

研究助成

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