研究のタイプ: 医学/生物学の研究 (experimental study)

[哺乳類の松果体に対する高周波電磁界の短期的影響はない] med./bio.

No short-term effects of high-frequency electromagnetic fields on the mammalian pineal gland.

掲載誌: Bioelectromagnetics 1997; 18 (5): 376-387

この研究は、高周波電磁界メラトニン合成に影響を与えるか否かを実験で調べた。ばく露に用いた900MHz電磁界は、連続波および217 Hzパルス変調波で、電力密度は0.1〜0.6mW / cm2であった。SARは、ラットでは約0.06〜0.36W / kg、ジャンガリアンハムスターでは0.04W / kgとなった。ばく露は、昼または夜に15分間~6時間行なった。その結果、いずれのばく露条件においても、オスおよびメスの、Sprague-Dawleyラットおよびジャンガリアンハムスターの、松果体メラトニン合成に明らかな短期的影響はなかった;松果体細胞シナプスリボン数(ラットのみで測定)も同様に影響を受けなかった、と報告している。

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研究目的(著者による)

To study whether short-term exposure to electromagnetic fields of 900 MHz has demonstrable effects on the pineal gland.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 15, 30, or 60 min
ばく露2: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 15, 30, or 60 min and 2, 4, or 6 h
  • 電力密度: 0.1 mW/cm² mean
  • SAR: 0.06 W/kg (in rats)
  • SAR: 0.04 W/kg (in Djungarian hamsters, exposed for 2 h only)
ばく露3: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 6 h
ばく露4: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 90 min

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 continuous for 15, 30, or 60 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • compact planar spiral antenna
Distance between exposed object and exposure source 385 mm
チャンバの詳細 The ventilated exposure box, made of plywood and covered with a hood, was completely shielded on the outside with an 0.1-mm aluminium foil and covered on the inside with flat absorber material. The box consisted of two compartments separated by a glass plate. The lower one contained the antenna, and the upper one received the polystyrene cage of 0.37 x 0.24 x 0.175 cm with three animals inside.
ばく露装置の詳細 The antenna in the first box produced a left-hand polarized field in the main radiation direction, i.e., the antenna axis. For simultaneous and sham exposure, an additional exposure box with a right-hand polarized antenna was used. The boxes were randomly selected for real and sham exposures.
Sham exposure A sham exposure was conducted.
Additional information In the first 12 experiments, real and sham exposures had to be carried out sequentially since only one box was available. In the following experiments (13-26), real and sham exposures were carried out simultaneously.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.1 mW/cm² mean 測定値 - -
SAR 0.06 W/kg - 推定値 - in rats

ばく露2

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 continuous for 15, 30, or 60 min and 2, 4, or 6 h
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Additional information

GSM standard

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.1 mW/cm² mean 測定値 - -
SAR 0.06 W/kg - 推定値 - in rats
SAR 0.04 W/kg - 推定値 - in Djungarian hamsters, exposed for 2 h only

ばく露3

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 continuous for 6 h
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Additional information

GSM standard

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.4 mW/cm² mean 測定値 - -
SAR 0.24 W/kg - 推定値 - in rats

ばく露4

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 continuous for 90 min
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Additional information

GSM standard

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.6 mW/cm² mean 測定値 - -
SAR 0.36 W/kg - 推定値 - in rats

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • pineal gland
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Both continuous and/or pulsed microwaves at day or night had no notable short-term effect on pineal melatonin synthesis in Sprague-Dawley rats and Djungarian hamsters. Pineal synaptic ribbon profile numbers were likewise not affected.
The 900 MHz electromagnetic fields, unpulsed or pulsed, have no short-term effect on the mammalian pineal gland.

研究の種別:

研究助成

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