研究のタイプ: 医学/生物学の研究 (experimental study)

[低レベルマイクロ波の反復ばく露後のラットの放射状迷路タスクの成績] med./bio.

Radial arm maze performance of rats following repeated low level microwave radiation exposure.

掲載誌: Bioelectromagnetics 2004; 25 (1): 49-57

この研究は、マイクロ波MW放射への全身ばく露後に、ラットのワーキングメモリが変化するか否かを実験で調べた。10日間毎日、円筒偏波導波管内で、全身SAR 0.6W.kgで、2450MHz(パルス幅2 μ秒、毎秒のパルス繰り返し数500)に45分間ばく露を行い、その後に12アームの放射迷路(RAM)で行動テストを実施した。ラットには、MWばく露前に精神作用薬3種の内のいずれか1種または生理食塩水の注射投与を行い、MWとの組合せの影響も調べた。誤り率(既進入のアームへの再進入の回数)、所要時間(12アームの先端におかれた餌を全て獲得するまでの時間)について、10日間の成績を分析した。その結果、誤り率に、MW単独、薬剤単独、その2つの相互効果のいずれも影響しなかった;10日間のばく露行動テストにおいて、実験の経過日数と2つの要因との相互効果は見られなかった、などを報告している。

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研究目的(著者による)

To examine possible changes in working memory of rats following whole body exposure to microwave irradiation.

詳細情報

Rats received a preexposure injection of one of three psychoactive compounds (physostigmine, naltrexone hydrochloride, naloxone methiodide) or saline, to determine whether a compound would interact with microwave irradiation to affect performance in the maze. The study was conducted as an attempt to confirm the results of a previous study (publication id 109).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: 45 min each on 10 testing days
  • SAR: 600 µW/g mean (whole body) (Dewar flask calorimetry and differential power method.)

ばく露1

主たる特性
周波数 2.45 GHz
ばく露時間 45 min each on 10 testing days
Modulation
Modulation type pulsed
Pulse width 2 µs
Packets per second 500
ばく露装置
ばく露の発生源/構造
チャンバの詳細 Plexiglass chamber
ばく露装置の詳細 waveguide constructed of galvanized wire screen in which a circularly polarized TE11 mode field configuration was realized
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 600 µW/g mean 測定値 whole body Dewar flask calorimetry and differential power method.

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Analyzes of error rates revealed no significant irradiation effect, no significant drug effect and no significant interaction between the two factors. There was a significant difference in test days with repeated test-trial days, which indicates that learning was accomplished. There was no significant interaction of test day and the other two main factors. The results of the analyzes of time it took each rat to enter all of the 12 baited arms included no significant exposure effect, a significant drug effect, a significant test day effect, and a significant interaction between drug and test day factors.
The authors concluded that there is no evidence from the current study that exposure to microwave irradiation under these parameters caused decrements in the ability of rats to learn the spatial memory task. These findings and those of other studies of possible working memory changes show differing results.

研究の種別:

研究助成

Replicated studies

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