研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波は放射状迷路におけるラットの行動に影響を与える] med./bio.

Microwave irradiation affects radial-arm maze performance in the rat.

掲載誌: Bioelectromagnetics 1994; 15 (2): 95-104

この研究は、パルス化2450MHzマイクロ波(2μ秒パルス、500pps、1mW / cm2、平均全身SARは0.6W / kg)への45分間ばく露が、ラット放射迷路での空間記憶に影響するか否かを調べた。その結果、ばく露後に、放射迷路で食餌の報酬を獲得する成績が低下することが示され、 空間的な「作業記憶」機能の障害が示唆された; この行動障害は、コリン作動性アゴニストであるフィゾスチグミンまたはアヘン拮抗薬ナルトレキソンばく露前投与により反転されたが、末梢アヘン拮抗薬ナロキソンメチオジドの事前投与では影響の反転はなかった、と報告している。

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研究目的(著者による)

To investigate whether cholinergic systems and endogenous opioids play a role in the microwave-induced spatial memory deficit in the radial-arm maze.

詳細情報

A series of experiments was carried out to study whether pretreatment with the cholinergic agonist physostigmine or the opiate antagonist naltrexone could reverse this behavioral effect of microwave exposure. In addition, since the origin (peripheral or central) of the endogenous opioid effect was not known, the effect of pretreatment with the peripheral opiate antagonist naloxone methiodide was also studied. If the behavioral effect involves only endogenous opioids inside the CNS, treatment with naloxone methiodide would have no significant effect on the spatial memory deficit.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 45 min

General information

Radial wooden 12- arm maze for behaviour test

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
特性
  • guided field
偏波
  • circular
ばく露時間 continuous for 45 min
Modulation
Modulation type pulsed
Pulse width 2 µs
Packets per second 500
ばく露装置
ばく露の発生源/構造
  • cylindrical waveguide exposure system, (8 cylindrical tubes)
チャンバの詳細 circular waveguide with circularly polarized TE11 mode field; Each tube containing a plastic chamber to house a rat
Additional information Source of exposure: described in Guy et al. [1979] Guy AW. Wallace J. McDougall JA (1979).
パラメータ
測定量 種別 Method Mass 備考
電力密度 10 W/m² mean 指定なし - -
SAR 600 µW/g mean 指定なし whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

After exposure the rats showed retarded learning while performing in the radial-arm maze to obtain food rewards (food was situated at the end of each arm), indicating a deficit in spatial working memory function. This behavioral deficit was reversed by pretreatment before radiation with the cholinergic agonist physostigmine or the opiate antagonist naltrexone. The pretreatment with the peripheral opiate antagonist naloxone methiodide showed no reversal of effect. The results indicate that both cholinergic and endogenous opioid neurotransmitter systems in the brain are involved in the microwave-induced spatial memory deficit.

研究の種別:

研究助成

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