この研究は、パルス化2450MHzマイクロ波（2μ秒パルス、500pps、1mW / cm2、平均全身SARは0.6W / kg）への45分間ばく露が、ラットの放射状迷路での空間記憶に影響するか否かを調べた。その結果、ばく露後に、放射状迷路で食餌の報酬を獲得する成績が低下することが示され、 空間的な「作業記憶」機能の障害が示唆された； この行動障害は、コリン作動性アゴニストであるフィゾスチグミンまたはアヘン拮抗薬ナルトレキソンのばく露前投与により反転されたが、末梢アヘン拮抗薬ナロキソンメチオジドの事前投与では影響の反転はなかった、と報告している。
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To investigate whether cholinergic systems and endogenous opioids play a role in the microwave-induced spatial memory deficit in the radial-arm maze.
A series of experiments was carried out to study whether pretreatment with the cholinergic agonist physostigmine or the opiate antagonist naltrexone could reverse this behavioral effect of microwave exposure. In addition, since the origin (peripheral or central) of the endogenous opioid effect was not known, the effect of pretreatment with the peripheral opiate antagonist naloxone methiodide was also studied. If the behavioral effect involves only endogenous opioids inside the CNS, treatment with naloxone methiodide would have no significant effect on the spatial memory deficit.
Radial wooden 12- arm maze for behaviour test
|ばく露時間||continuous for 45 min|
|Pulse width||2 µs|
|Packets per second||500|
|チャンバの詳細||circular waveguide with circularly polarized TE11 mode field; Each tube containing a plastic chamber to house a rat|
|Additional information||Source of exposure: described in Guy et al.  Guy AW. Wallace J. McDougall JA (1979).|
After exposure the rats showed retarded learning while performing in the radial-arm maze to obtain food rewards (food was situated at the end of each arm), indicating a deficit in spatial working memory function. This behavioral deficit was reversed by pretreatment before radiation with the cholinergic agonist physostigmine or the opiate antagonist naltrexone. The pretreatment with the peripheral opiate antagonist naloxone methiodide showed no reversal of effect. The results indicate that both cholinergic and endogenous opioid neurotransmitter systems in the brain are involved in the microwave-induced spatial memory deficit.