目的は、オスラットの甲状腺ホルモンと行動に対する漏れマイクロ波放射の影響を解析することでる。【方法】2グループ（ばく露と対照）のオスラットを実験に用い、RIA法で3, 5, 3´トリヨードチロニン (T3)、サイロキシン (T4)、TSHを求めた。行動の評価は、オープン場（OF）とメーズ装置（EPM）で行った。【結果】慢性的にマイクロ波を照射後、ラットは16日目と21日目に過度に活発になり、また攻撃的になった。OFでの行動変化を分析し、動かなくなり、立ち上がったり、歩行などの行動が対照群とは異なることがわかった（p<0.05）。EPMでは、照射後、11、16、21日目で、ラットはオープン部で過ごすのが減少し中央部で過ごす時間が多くなった。また対照と比べて、行動変化のパラメータが、血液中のホルモンレベルの変化と同じように関連する傾向が見られた。T3（16日、21日で減少）、T4（21日で増加）。【結論】低エネルギーのマイクロ波放射は、対照群と比較するばく露群では甲状腺ホルモンレベル、感情反応に変化を及ぼすので、有害であることが言えるかもしれない。
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To determine the effects of chronic exposure to low energy 2450 MHz nonthermal microwave irradiation on thyroid hormones and to analyze how these changes in thyroid hormones, if any, affect the reactiveness and emotional behavior of rats.
Twenty male rats of 4-5 weeks of age were analyzed. Blood was taken from the tails of each rat on the 1st, 6th, 11th, 16th and 21st day immediately after two hours irradiation or sham exposure.
Modulation type: pulsed
ばく露時間: repeated daily exposure, 2 h/day, for up to 21 days
|ばく露時間||repeated daily exposure, 2 h/day, for up to 21 days|
|Repetition frequency||1 kHz|
|Distance between exposed object and exposure source||23 cm|
|チャンバの詳細||The flair angle of the antenna was 9.6° in both the electric (E) and the magnetic (H) plane. The distance of the antenna from the top of the animal holder was 23 cm. The 3 dB points for both H and E planes were calculated and used in the design of the animal holder for five rats that consisted of a Perspex box with five compartments on a 10-cm Styrofoam base of 29.87 x 25.3 cm. The internal partitioning was made of pine wood due to its low dielectric constant and loss tangent. All external and internal walls, excluding the base were perforated at uniform distances to make the holder anechoic. An absorber made of carbon coated Styrofoam with cones on its surface was placed below the holder to reduce reflected radiation.|
|ばく露装置の詳細||The long axis was positioned parallel to the E-field for two of the compartments and parallel to the H-field for the other three. Rats were not restrained and were free to change their posture within the cage. They were rotated daily from one chamber to the next chamber in succession.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Tests and analyses were performed on the 1st, 6th, 11th, 16th and 21st day of the experiment immediately after RF or sham exposure.|
Concerning behavioral changes in open field, significant increase in mobility, rearing, and central/peripherial ambulation were found in exposed rats on the 16th and 21st days of exposure. In elevated plus maze, rats showed increased activity with decreased time spent in the open arm and more time spent in the center on the 11th, 16th and 21st day after irradiation. The changes in behavioral parameters were accompanied by decreased levels of triiodothyronine on the 16th day and 21st day and increased levels of thyroxine on the 21st day of exposure.
The authors conclude that low energy microwave irradiation may be harmful as it is sufficient to alter the levels of thyroid hormones as well as the emotional reactivity of rats.