研究のタイプ: 医学/生物学の研究 (experimental study)

[ラット脳細胞でのDNA単鎖および2重鎖の切断に対するマイクロ波および時間的非コヒーレント磁界の相互作用] med./bio.

Interaction of Microwaves and a Temporally Incoherent Magnetic Field on Single and Double DNA Strand Breaks in Rat Brain Cells.

掲載誌: Electromagn Biol Med 2005; 24 (1): 23-29

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研究目的(著者による)

To study whether simultaneous exposure to a temporally incoherent magnetic field ("noise") could attenuate microwave-induced increases in DNA single-strand breaks and double-strand breaks in brain cells of the rat.

詳細情報

Four treatment groups of rats were investigated: microwave-exposure, noise-exposure (45 mG), microwave + noise-exposure, and sham-exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2,450 MHz
Modulation type: CW
ばく露時間: continuous for 2 h
  • 電力密度: 1 mW/cm²
  • SAR: 0.6 W/kg average over mass (whole body) ([Chou et al., 1984])
ばく露2: 30–100 Hz
ばく露時間: continuous for 2 h

General information

Animals were exposed to MW alone, MW plus noise, and noise alone. A sham-exposed animal was included in each run.

ばく露1

主たる特性
周波数 2,450 MHz
タイプ
  • electromagnetic field
特性
  • guided field
偏波
  • circular
ばく露時間 continuous for 2 h
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 Cylindrical waveguides made of galvanized wire screen were excited in TE11 mode [Guy et al., 1979]. Each waveguide contained a plastic chamber to house a rat with enough space to move and a floor made of glass rods.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 1 mW/cm² - - - -
SAR 0.6 W/kg average over mass 備考を参照のこと。 whole body [Chou et al., 1984]

ばく露2

主たる特性
周波数 30–100 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 2 h
Additional information band-limited ELF noise
Modulation
Modulation type cf. additional information
Additional information

The incoherent magnetic field (ELF noise) was generated using a signal recorded in an audiocassette tape.

ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 For incoherent magnetic field exposure, a waveguide was placed between a pair of Helmholtz coils which were positioned across the plastic cage. E-field shielding was provided by connecting the coil frame made of flexible copper tubing to electrical ground.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 4.5 µT mean 測定値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Data show that brain cells of microwave-exposed rats had significantly higher levels of DNA single-strand breaks and double-strand breaks when compared with sham-exposed animals. Exposure to noise alone did not significantly affect the levels. However, simultaneous noise exposure blocked microwave-induced increases in DNA strand breaks.
These findings indicate that simultaneous exposure to a temporally incoherent magnetic field could block microwave-induced DNA damage in brain cells of the rat.

研究の種別:

研究助成

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