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The effects of an acute exposure of Escherichia coli to 60 Hz magnetic fields with different strengths on the cytotoxic potency and membrane permeability of two anti-cancer drugs should be investigated.
The investigated drugs were mitomycin C and cisplatin. An enhancing effect of a 60 Hz magnetic field with 50 mT on the cytotoxic potency of mitomycin C had already been observed in previous tests by the authors (no reference). Changes in the membrane permeability depending on the magnetic flux density were assumed as the underlying mechanism of action.
|ばく露時間||continuous for 6 h|
|ばく露装置の詳細||the temperature within the experimental area was controlled by circulating water at 36°C|
|Sham exposure||A sham exposure was conducted.|
A significant decrease of the cell viability was found in tests with both drugs and simultaneous exposure to the magnetic field compared to approaches without magnetic field exposure. This was interpreted as an increase of the cytotoxic potency of the drugs. The strongest effect in tests with mitomycin C was observed for a magnetic flux density of 50 mT. The tests with the supernatants of the tests above showed a significantly reduced potency of the approaches with magnetic field exposure compared to the supernatants without exposure. This was interpreted as an increased intracellular and decreased extracellular concentration of both drugs in tests with magnetic field exposure, which was explained by a significantly increased membrane permeability.
The authors conclude that an acute exposure to 60 Hz magnetic fields with 50 mT increases the membrane permeability and thus the uptake of mitomycin C and cisplatin in E. coli which leads to a enhancement of their cytotoxic potency.