研究のタイプ: 医学/生物学の研究 (experimental study)

[抗がん剤の効力に対する超低周波(ELF)磁界の影響] med./bio.

Effect of Extremely Low-Frequency (ELF) Magnetic Fields on Anticancer Drugs Potency.

掲載誌: IEEE Trans Magn 2012; 48 (11): 2869-2872

この研究は、大腸菌に対する抗がん剤の細胞毒性作用を磁界(60 Hz、50 mT)が増強するか否かを調べた。その結果、マイトマイシンCの効力増強が磁束密度に依存して観察された;シスプラチンの効力も磁界ばく露により増強された;このメカニズムとして、磁界による細胞膜の透過性変化および薬剤取り込みへの影響が示唆されたと報告している。

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研究目的(著者による)

The effects of an acute exposure of Escherichia coli to 60 Hz magnetic fields with different strengths on the cytotoxic potency and membrane permeability of two anti-cancer drugs should be investigated.

詳細情報

The investigated drugs were mitomycin C and cisplatin. An enhancing effect of a 60 Hz magnetic field with 50 mT on the cytotoxic potency of mitomycin C had already been observed in previous tests by the authors (no reference). Changes in the membrane permeability depending on the magnetic flux density were assumed as the underlying mechanism of action.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous for 6 h

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 6 h
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 the temperature within the experimental area was controlled by circulating water at 36°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 50 mT - 測定値 - -
磁束密度 30 mT - 測定値 - -
磁束密度 5 mT - 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

A significant decrease of the cell viability was found in tests with both drugs and simultaneous exposure to the magnetic field compared to approaches without magnetic field exposure. This was interpreted as an increase of the cytotoxic potency of the drugs. The strongest effect in tests with mitomycin C was observed for a magnetic flux density of 50 mT. The tests with the supernatants of the tests above showed a significantly reduced potency of the approaches with magnetic field exposure compared to the supernatants without exposure. This was interpreted as an increased intracellular and decreased extracellular concentration of both drugs in tests with magnetic field exposure, which was explained by a significantly increased membrane permeability.
The authors conclude that an acute exposure to 60 Hz magnetic fields with 50 mT increases the membrane permeability and thus the uptake of mitomycin C and cisplatin in E. coli which leads to a enhancement of their cytotoxic potency.

研究の種別:

研究助成

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