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To study whether exposure of rat brain to microwaves of global system for mobile communication (GSM) induces DNA strand breaks, changes in chromatin conformation and in gene expression.
|ばく露時間||continuous for 2 h|
|チャンバの詳細||The output of a GSM900 test mobile phone was connected by coaxial cable to a TEM cell which has been described previously in the reference article. In principle, this is a spliced coaxial cable with a central electrode and an outer shield electrode with the unique characteristic of having both linear amplitude and phase response versus frequency and allowing relatively homogeneous exposures of samples.|
|ばく露装置の詳細||Rats were not restrained during exposure inside the TEM cell. The power of the test phone was kept constant at 33 dBm (2 W) and monitored online using a power meter.|
|Additional information||Sham exposures were performed in the same TEM cell with MW power off. The order of four independent MW and sham exposures was randomized among sessions on four consecutive days.|
Effects of microwave exposure were found on neither conformation of chromatin nor DNA double-strand breaks.
In cerebellum from all exposed animals, 11 genes were upregulated in a range of 1.34-2.74 fold and one gene was downregulated 0.48-fold. The induced genes encode proteins with diverse functions including neurotransmitter regulation, blood-brain barrier, and melatonin production.
The results show that GSM microwaves at 915 MHz did not induce DNA double-strand breaks or changes in chromatin conformation, but affected gene expression in rat brain cells.
Because the nonthermal effects of microwaves appear to be dependent of many physical and biological variables, the data of this study should be compared with care with other studies where these variables are different.