研究のタイプ: 疫学研究 (observational study)

[発電所の男性労働者における血漿ホルモン性および炎症性の経路のバイオマーカに対する電磁界ばく露の影響] epidem.

Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant.

掲載誌: Int Arch Occup Environ Health 2016; 89 (1): 33-42

この研究は、発電所で高い電磁界職業ばく露された男性労働者77人および年齢でマッチングした低ばく露の労働者77人について、血漿ホルモン性および炎症性の経路のバイオマーカーに対する電磁界ばく露の影響を評価した。社会人口統計学的特徴、生活様式、電磁界ばく露についての関連情報はアンケートで得た。テストステロンエストラジオールメラトニン、NF-κB、熱ショックタンパク質HSP)70、HSP27、TET1の血漿レベルは酵素免疫測定法(ELISA)で判定した。その結果、ばく露群は対照群と比較して、テストステロン(β=-0.3nmol/L、P=0.015)、テストステロンエストラジオール(T/E)比(β=-15.6、P=0.037)、NF-κB(β=-20.8ng/L、P=0.045)が統計的に有意に低かった。更に、テストステロンのレベルおよびT/E比に対する、電磁界への職業ばく露と雇用期間、携帯電話料金、携帯電話の使用年数、電気料金との連合効果が認められた。但し、電磁界ばく露エストラジオールメラトニン、HS70、HSP27、TET1の血漿レベルとの統計的に有意な関連は認められなかった。著者らは、これらの知見は、電磁界への慢性ばく露は男性の血漿テストステロンおよびT/E比を低下させる可能性があり、それによって生殖機能に影響を及ぼすかも知れないことを示している、と結論付けている。

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研究の目的(著者による)

A case-control study was conducted in China to evaluate the effects of occupational exposure to electromagnetic fields on levels of plasma hormones and inflammatory pathway biomarkers in male workers of a power plant.

詳細情報

The results on serum lipids investigated in a subgroup of same study population were published by Wang et al (2015).
A blood sample was taken from each participants to analyze hormonal and biomarker levels.
Remark EMF-Portal: The classification into 'low occupational EMF exposure' and 'high occupational EMF exposure' is not clear.

影響評価項目/リスク推定のタイプ

リスク推定のタイプ:

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 low occupational exposure: no walkie-talkies use, daily exposure < 4 h, employment duration < 15 years
集団 2 high occupational exposure: walkie-talkies use, daily exposure ≥ 4 h, employment duration ≥ 15 years
参照集団 3 low occupational exposure, employment duration: < 23 years
集団 4 low occupational exposure, employment duration: ≥ 23 years
集団 5 high occupational exposure, employment duration: < 23 years
集団 6 high occupational exposure, employment duration: ≥ 23 years
参照集団 7 low occupational exposure, daily duration: ≤ 4 hours/day
集団 8 low occupational exposure, daily duration: > 4 hours/day
集団 9 high occupational exposure, daily duration: ≤ 4 hours/day
集団 10 high occupational exposure, daily duration: > 4 hours/day
参照集団 11 low occupational exposure and mobile phone use: ≤ 12 years
集団 12 low occupational exposure and mobile phone use: > 12 years
集団 13 high occupational exposure and mobile phone use: ≤ 12 years
集団 14 high occupational exposure and mobile phone use: > 12 years
参照集団 15 low occupational exposure and mobile phone fee: < 60 yuan/month
集団 16 low occupational exposure and mobile phone fee: ≥ 60 yuan/month
集団 17 high occupational exposure and mobile phone fee: < 60 yuan/month
集団 18 high occupational exposure and mobile phone fee: ≥ 60 yuan/month
参照集団 19 low occupational exposure and monthly electric fee: ≤ 150 yuan/month
集団 20 low occupational exposure and monthly electric fee: > 150 yuan/month
集団 21 high occupational exposure and monthly electric fee: ≤ 150 yuan/month
集団 22 high occupational exposure and monthly electric fee: > 150 yuan/month

調査対象集団

調査規模

タイプ
合計 2,138
参加者 747
評価可能 154
統計学的分析方法:

結論(著者による)

The average measured intensity of occupational exposure was 316.3±1212.3 V/m for electric field and 6.17±14.71 µT for magnetic fields in high exposure group, which far outstripped that in low exposure group (3.9±0.3 V/m and 60.6±16.9 nT, respectively).
Significantly lower levels of testosterone and NF-KB and a significantly reduced testosterone/estradiol ratio were observed in workers with higher occupational exposure (group 2) in comparison to the reference group 1. No significant associations were found for estradiol, melatonin, or for the inflammatory pathway biomarkers HSP70, HSP27, or TET1. High exposure groups with longer employment duration, longer mobile phone use, higher mobile phone fee or higher electric fee per month showed lower levels of testosterone and testosterone/estradiol ratio compared to the respective reference groups.
The authors concluded that chronic exposure to electromagnetic fields could decrease male plasma testosterone and testosterone/estradiol ratio.

研究助成

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