研究のタイプ: 医学/生物学の研究 (observational study)

[132 kV変電所で超低周波電磁界ばく露を受けた作業者のエピネフリン、DNA完全性、酸化ストレス] med./bio.

Epinephrine, DNA integrity and oxidative stress in workers exposed to extremely low-frequency electromagnetic fields (ELF-EMFs) at 132 kV substations.

掲載誌: Electromagn Biol Med 2015; 34 (1): 56-62

この研究は、132 kV高圧変電所で、超低周波電磁界(ELF-EMF)に2年間以上職業的にばく露を受けている男性労働者群142人と、彼らと年齢、社会経済状態をマッチさせ選出した、ELF-EMFばく露がない対照群151人からの血液標本を分析した。その結果、ばく露レベルの高、中、低群の血中エピネフリン平均値は、75.22±1.46、64.43±8.26、48.47±4.97であった(アブストラクトに記載されているのみで、文中で詳しい説明はない);DNA損傷に関しては、コメットテール長が1.69-9.91 μmの範囲であった(対照群は1.44-7.38 μm);ばく露群では酸化ストレスレベル上昇が見られた、と報告している。

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研究目的(著者による)

The effects of occupational exposure to extremely low frequency fields in substations on the adrenaline level, DNA damage and oxidative stress in the blood should be investigated.

詳細情報

Further results on this study population are published in Tiwari et al (2013).
A total of 293 male volunteers participated in the study and were divided into two groups: an exposure group (n=142) including subjects with occupational exposure to high voltage substations for more than 2 years, and the control group (n=151) including individuals without such an exposure. The age, socioeconomic status and lifestyle factors were matched between both groups. A blood sample was taken from each subject between 8 and 10 o'clock in the morning.
The exposure group was partly divided into the following subgroups: based on distance of work place to a transformer: 1) less than 2 m (n=?), 2) less than 10 m (n=?); based on total exposure duration: 3) 2-5 year (n=42), 4) 6-13 years (n=45), 5) 14-30 years (n=55); based on frequency of exposure (hours/day): 6) 1-3 h (n=59), 7) 4-6 h (n=45), 8) 7-9 h (n=38); based on exposure level (depending on job title): 9) low (n=87), 10) medium (maintenance; n=44), 11) high (live-line work; n=11).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: intermittent for 1-9 hours/day for 2-30 years (mean of 9 years)
-

ばく露1

主たる特性
周波数
タイプ
  • electric field
  • magnetic field
ばく露時間 intermittent for 1-9 hours/day for 2-30 years (mean of 9 years)
ばく露装置
ばく露の発生源/構造
  • power line and transformers
ばく露装置の詳細 132 kV high-voltage substations
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant changes in the adrenaline level were found between the exposure group and the control group or between the subgroups.
A tendency towards increased DNA damage in the exposure group compared to the control group was found though the significance was not stated.
Regarding oxidative stress, the lipid peroxidation concentration was significantly increased in the exposure group compared to the control group (remark EMF-Portal: the significance specifications for nitric oxide were contradictory).
The total exposure duration had a significant effect on oxidative stress with the highest values found in subgroup 5 (exposure for more than 14 years). However, no consistent trend was found.
Regarding the exposure level, subgroup 11 (high level) showed significantly increased oxidative stress parameters compared to subjects with a lower exposure level (subgroups 9 and 10). A medium exposure level (subgroup 10) resulted in a significantly increased lipid peroxidation compared to a low exposure level (subgroup 9).
The authors conclude that occupational exposure to extremely low frequency fields in substations could induce oxidative stress in the blood depending on the level of exposure.

研究の種別:

研究助成

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