研究のタイプ: 医学/生物学の研究 (observational study)

[頬粘膜上皮細胞小核試験による携帯電話放射の遺伝毒性の解析:比較による評価] med./bio.

Analysis of the Genotoxic Effects of Mobile Phone Radiation using Buccal Micronucleus Assay: A Comparative Evaluation.

掲載誌: J Clin Diagn Res 2016; 10 (3): ZC82-ZC85

この研究は、携帯電話の軽度使用者群(使用年数5年未満、1週間の通話時間3時間未満:n=150)と重度使用者群(同5年以上、同10時間以上:n=150)から採取した剥離頬粘膜上皮細胞での小核MN)試験結果を比較した。被験者は20-30歳の男性健常者である。その結果、MN出現頻度は軽度使用者群に比べ重度使用者群で有意に高かった、と報告している。

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研究目的(著者による)

The genotoxic effects of exposure to mobile phones in the oral mucosa of mobile users should be investigated.

詳細情報

A total of 300 subjects (ambulant patients of the department of oral pathology and microbiology) filled out a questionnaire on lifestyle, dietary habit, previous history of medication, locality of residence, type of mobile used (CDMA or GSM; only group 2), duration of mobile phone usage (number of years and numbers of hours a week), use of headsets (only group 2), wired or not, associated symptoms like headaches, tingling of skin, rashes over the skin and warmth of the ear.
Subsequently, subjects were divided into 2 groups (n=150 each) according to their mobile usage: 1) low mobile phone users (use of mobile phone for less than 5 years and less than 3 hours a week) and 2) high mobile phone users (mobile phone usage for more than 5 years and more than 10 hours a week).
Exfoliated buccal mucosal cells were collected from the same side on which the subject used their mobile phones the most. Only in group 2, a comparative evaluation was done between both the sides of buccal mucosa (right and left).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: mobile use for less than 5 years and less than 3 hours a week
low users
-
ばく露2:
ばく露時間: mobile use for more than 5 years and more than 10 hours a week
high users
-

General information

receiving or making calls was considered as exposure, while net surfing and text messaging was not included; in group 2, 95 subjects were CDMA users and 55 subjects were GSM users and 70 subjects used wired headset while 80 were non-headset users

ばく露1

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 mobile use for less than 5 years and less than 3 hours a week
Additional information low users
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
パラメータ

No parameters are specified for this exposure.

ばく露2

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 mobile use for more than 5 years and more than 10 hours a week
Additional information high users
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

There was a significant increase in the mean micronuclei count in high mobile phone users (group 2) compared to low mobile phone users (group 1).
In group 2, the number of micronuclei was significantly elevated at the side of mobile phone use in comparison to the opposite side. The micronuclei mean count was also found to be significantly increased in non-headset users compared to headset users. The highest amount of micronuclei was found in users of group 2 without headset, who complained about warmth around the ear.
No significant differences were found between GSM and CDMA users.
The authors conclude that long-term exposure to mobile phones might have genotoxic effects on the oral mucosa and that the use of headsets could attenuate these effects.

研究の種別:

研究助成

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