[頬粘膜上皮細胞小核試験による携帯電話放射の遺伝毒性の解析：比較による評価] med./bio.

The genotoxic effects of exposure to mobile phones in the oral mucosa of mobile users should be investigated.

A total of 300 subjects (ambulant patients of the department of oral pathology and microbiology) filled out a questionnaire on lifestyle, dietary habit, previous history of medication, locality of residence, type of mobile used (CDMA or GSM; only group 2), duration of mobile phone usage (number of years and numbers of hours a week), use of headsets (only group 2), wired or not, associated symptoms like headaches, tingling of skin, rashes over the skin and warmth of the ear.
Subsequently, subjects were divided into 2 groups (n=150 each) according to their mobile usage: 1) low mobile phone users (use of mobile phone for less than 5 years and less than 3 hours a week) and 2) high mobile phone users (mobile phone usage for more than 5 years and more than 10 hours a week).
Exfoliated buccal mucosal cells were collected from the same side on which the subject used their mobile phones the most. Only in group 2, a comparative evaluation was done between both the sides of buccal mucosa (right and left).

• ヒト
• 身体の一部: head

There was a significant increase in the mean micronuclei count in high mobile phone users (group 2) compared to low mobile phone users (group 1).
In group 2, the number of micronuclei was significantly elevated at the side of mobile phone use in comparison to the opposite side. The micronuclei mean count was also found to be significantly increased in non-headset users compared to headset users. The highest amount of micronuclei was found in users of group 2 without headset, who complained about warmth around the ear.
No significant differences were found between GSM and CDMA users.
The authors conclude that long-term exposure to mobile phones might have genotoxic effects on the oral mucosa and that the use of headsets could attenuate these effects.