研究のタイプ: 医学/生物学の研究 (observational study)

[携帯電話使用者の口腔上皮剥離細胞における核の異常の評価] med./bio.

Assessment of nuclear abnormalities in exfoliated cells from the oral epithelium of mobile phone users.

掲載誌: Electromagn Biol Med 2014; 33 (2): 98-102

この研究は、携帯電話使用者から採取した口腔上皮の剥離細胞を検査して、携帯電話電磁界遺伝毒性および細胞毒性の可能性を評価した。ボランティア45人は、携帯電話の使用量(t = 1週間当たりの通話時間[h])による次の3群(各15人)に分かれた;第I群(t > 5 h); 第II群(1 < t ≦5 h); 第III群(t≦1 h)。毒性指標として、口腔粘膜細胞における小核出現頻度、broken egg構造、または、クロマチン凝集・核崩壊・核凝縮・核溶解などアポトーシスまたは壊死に関係する変性的核異常を評価した。その結果、小核出現頻度および変性的核異常には3群間に差がなかった;broken egg構造(遺伝子増幅に伴う変化かも知れないと著者は言う)が第I群で有意に多かった、と報告している。

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研究目的(著者による)

Genotoxic and cytotoxic effects of a chronic exposure to electromagnetic fields emitted by mobile phones on exfoliated oral epithelial cells should be measured.

詳細情報

45 individuals were divided into three groups according to the amount of time in hours per week that they spend using their mobile phones: a) more than 5 hours, b) 1 - 5 hours, c) less than 1 hour per week.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 850–1,900 MHz
ばく露時間: > 5 hours mobile phone use per week
  • SAR: 1.38 W/kg maximum (of the mobile phones used - according to manufacturer)
  • SAR: 0.344 W/kg minimum (of the mobile phones used - according to manufacturer)
ばく露2: 850–1,900 MHz
ばく露時間: 1-5 hours mobile phone use per week
  • SAR: 1.38 W/kg maximum (of the mobile phones used - according to manufacturer)
  • SAR: 0.452 W/kg minimum (of the mobile phones used - according to manufacturer)
ばく露3: 850–1,900 MHz
ばく露時間: ≤ 1 hour mobile phone use per week
  • SAR: 1.22 W/kg maximum (of the mobile phones used - according to manufacturer)
  • SAR: 0.36 W/kg minimum (of the mobile phones used - according to manufacturer)

General information

no exposure took place as part of the experimental setup (observational study)

ばく露1

主たる特性
周波数 850–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 > 5 hours mobile phone use per week
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
パラメータ
測定量 種別 Method Mass 備考
SAR 1.38 W/kg maximum - - of the mobile phones used - according to manufacturer
SAR 0.344 W/kg minimum - - of the mobile phones used - according to manufacturer

ばく露2

主たる特性
周波数 850–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 1-5 hours mobile phone use per week
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
パラメータ
測定量 種別 Method Mass 備考
SAR 1.38 W/kg maximum - - of the mobile phones used - according to manufacturer
SAR 0.452 W/kg minimum - - of the mobile phones used - according to manufacturer

ばく露3

主たる特性
周波数 850–1,900 MHz
タイプ
  • electromagnetic field
ばく露時間 ≤ 1 hour mobile phone use per week
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
パラメータ
測定量 種別 Method Mass 備考
SAR 1.22 W/kg maximum - - of the mobile phones used - according to manufacturer
SAR 0.36 W/kg minimum - - of the mobile phones used - according to manufacturer

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Neither the occurrence of micronuclei nor the amount of apoptotic and necrotic cells was significantly different between the groups. Only the amount of broken egg structures was significantly higher in group a) compared to groups b) and c). However, the causes and the biological significance of these structures have not been clarified to date.
The authors conclude that their results give no indications of genotoxic or cytotoxic effects by the usage of mobile phones on oral epithelial cells.

研究の種別:

研究助成

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