研究のタイプ: 医学/生物学の研究 (observational study)

[携帯電話ユーザの口腔粘膜細胞における小核形成頻度] med./bio.

Micronucleus frequency in buccal mucosa cells of mobile phone users.

掲載誌: Toxicol Lett 2010; 193 (1): 124-130

このボランティア実験研究は、ヒトの口腔粘膜細胞のゲノム不安定性に対する携帯電話使用の影響を調べた。大学内での学生・大学職員募集、、新聞での一般人募集などにより集められた被験者131名は綿棒採取した頬粘膜細胞を提供し、質問紙(年齢、性別、肥満度、喫煙、化学療法剤やX線、栄養習慣の他に、携帯電話使用に関しては、1週間の使用時間、使用期間、ヘッドセットの利用など。)に回答した。その結果、携帯電話使用歴無し:13名、使用時間が≦3時間/週:85名、> 3時間/週:33名であった;携帯電話使用と口腔粘膜細胞の小核形成頻度上昇には有意な関連はなかった、などの所見を報告している。

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研究目的(著者による)

To investigate the effect of mobile phone use on genomic instability of the human oral cavitiy's mucosa cells.

詳細情報

The study of Yadav et al (2008) in which increased numbers of micronuclei among mobile phone users were found should be replicated. In the present study a higher number of participants (n=131) was examined and a double amount of cells (2000 cells/individual) was counted to increase the statistical power. Furthermore a different, DNA-specific staining procedure was applied.
Each participant filled out a questionnaire about mobile phone use including duration of weekly use, overall period of use and headset usage for exposure assessment. The participants were divided into eleven groups: no use of mobile phones, 0-3 h/week, >3-6 h/week, >6-9 h/week, >9-12 h/week, and >12-15 h/week; <5 years, 5-10 years and >10 years period of mobile phone use; use and non-use of headsets.
Cells of four patients after four weeks of radiotherapy served as positive controls for the micronucleus test.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
  • unspecified
ばく露時間: up to 15 hr/week for up to 10 years and more
-

ばく露1

主たる特性
周波数
  • unspecified
タイプ
  • electromagnetic field
ばく露時間 up to 15 hr/week for up to 10 years and more
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No differences in micronucleus frequencies were found between persons with different periods of duration (in years) of mobile phone use. No differences in micronucleus frequencies were observed between head set users or persons without headset use. No influence on the micronucleus frequencies was found for different duration of daily mobile phone use (h/week).
The authors concluded that mobile phone use did not lead to significantly higher number of micronuclei. The results of study by Yadav et al (2008) could not be confirmed.

研究の種別:

研究助成

Replicated studies

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