研究のタイプ: 医学/生物学の研究 (experimental study)

Age-related differences in serum melatonin and pineal NAT activity and in the response of rat pineal to a 50-Hz magnetic field. med./bio.

掲載誌: Life Sci 1999; 64 (24): 2291-7

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研究目的(著者による)

The effects of exposure of young and aged rats to a 50 Hz magnetic field on the pineal gland should be investigated.

詳細情報

In a previous study (Selmaoui and Touitou 1995), the authors found that exposure to a 50 Hz magnetic field could suppress the nocturnal peak of melatonin in young rats. Since aging is characterized by a decrease in adaptiveness of the organism to environmental changes, and melatonin levels in old rats are lower than in young ones, the authors hypothesized that old rats might react differently than younger ones.
Rats were divided into the following groups (n=6, respectively): 1) exposure of young rats to the magnetic field, 2) exposure of aged rats to the magnetic field, 3) sham exposure of young rats, 4) sham exposure of aged rats. After exposure, all rats were killed and investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: 18 hours/day for 1 week

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 18 hours/day for 1 week
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 eight shelves were equipped with an exposure system (6 rectangular coils) programmed to switch the field on and off at 14:00 and 08:00, respectively; sham exposed and exposed animals were handled and maintained simultaneously under the same conditions; the MF was uniform in all exposure boxes without any interaction between them; sham exposed animals were kept sufficiently spaced from exposed ones to avoid any interaction
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 100 µT - - - -

Reference articles

  • Selmaoui B et al. (1995): [50 Hz正弦波磁界はラットの血清メラトニン値と松果体のNAT活性を抑制する:ばく露時間と強度の役割]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Exposure to the magnetic field resulted in a significant decrease in serum melatonin and serotonin N-acetyltransferase enzyme activity in young rats (group 1) compared to their sham exposure group (group 3).
In aged rats, no significant effects of exposure to the magnetic field were observed. However, serum melatonin levels and N-acetyltransferase enzyme activity were decreased in sham exposed aged rats (group 4) compared to sham exposed young rats (group 3) (decrease by about 38% and 36%, respectively) confirming the generally lower melatonin levels in aged rats.
The authors conclude that exposure to a 50 Hz magnetic field might attenuate pineal gland function in young rats, while aged rats seem to be insensitive.

研究の種別:

研究助成

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