研究のタイプ: 医学/生物学の研究 (experimental study)

[2.45 GHzマイクロ波のばく露後のマウス胎仔の観察] med./bio.

Observations of mouse fetuses after irradiation with 2.45 GHz microwaves.

掲載誌: Health Phys 1978; 35 (6): 791-801

この研究は、妊娠中のCD-1マウスに、2.45 GHzの連続波を、100分間、一定範囲の電力密度(3.4〜28 mW/ cm 2)でばく露し、出産間近の胎仔の肉眼的外部形態変化を調べた。その結果、一腹当たりの平均生存胎児体重は、最も高い電力密度へのばく露群において有意に低下した(擬似ばく露群0.97 ± 0.15 g;ばく露群0.89 ± 0.13 g);ばく露群では、頭蓋裂の発生率が有意に高くなった;実験に用いた電力密度の範囲では、100分間ばく露よる母マウスの平均SARは、2.0 – 22.2 mW/ gと推定された、と報告している。

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研究目的(著者による)

This in vivo study was performed to investigate the effects of microwave exposure during pregnancy in mice fetuses.

詳細情報

A total of 1008 female mice (589 sham exposed and 519 mice microwave exposed) were used. All pregnant mice were killed on the 18th day after breeding and their fetuses examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: continuous for 100 min/day for up to 17 days

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 continuous for 100 min/day for up to 17 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
チャンバの詳細 polycarbonate plastic cage 6 cm on a side, 1.5 mm thick; 1mm thick pvc plastic lid, 6-8 ventilation holes at each side with 5 mm diameter
ばく露装置の詳細 cages placed in styrofoam forms to ensure the exact positioning in the field
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 3.4 mW/cm² minimum 計算値 - 3.4, 13.6, 14, 28 mW/cm²
電力密度 28 mW/cm² maximum 計算値 - -
SAR 4.05 mW/g mean 計算値 unspecified 4.05 - 7.37 mW/g

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The microwave exoposure at the highest power density (28 mW/cm2) decreased significantly the mean live fetal weight per litter. A significantly increased incidence of cranioschisis (congenital failure of the skull to close, usually accompanied by defective development of the brain) was observed in exposed fetuses.
The exposure of the dams at either power density did not result in higher core temperature. Therfore, a thermal cause as reason for the observed effects on fetus can be excluded.
It appears that microwaves at the range used could be teratogenic.

研究の種別:

研究助成

関連論文