研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの血清中ホルモンレベルに対するCDMAおよびWCDMA電磁界の組合せ同時ばく露の影響] med./bio.

Effects of simultaneous combined exposure to CDMA and WCDMA electromagnetic fields on serum hormone levels in rats.

掲載誌: J Radiat Res 2013; 54 (3): 430-437

この研究は、CDMA(849MHz)およびWCDMA(1.95GHz)の無線周波RF)信号に45分間/日、5日/週、8週間にわたって同時ばく露したSprague-Dawleyラット240匹(擬似ばく露群(雌雄各40匹)、CDMA(全身平均SAR 4W/kg)ばく露群(雌雄各40匹)、CDMA+WCDMA(それぞれ全身平均SAR 2W/kg で合計4W/kg)ばく露群(雌雄各40匹))を各群半数は4週間ばく露後に屠殺、残り半数は8週間後に屠殺し、内分泌系の複数のパラメータを調べた。その結果、8週間の同時ばく露において、メラトニン甲状腺刺激ホルモン、トリヨードチロニン、チロキシン、副腎皮質刺激ホルモン、性ホルモンテストステロンおよびエストロゲン)の血中濃度に影響は見られなかった、と報告している。

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研究目的(著者による)

To investigate several parameters of the endocrine system after exposure to a single CDMA or a combined CDMA and WCDMA signal.

詳細情報

Rats were divided into three groups, each group consisted of 40 male and 40 female rats: 1.) sham exposure, 2.) exposure to CDMA and 3.) exposure to CDMA and WCDMA. After 4 weeks of exposure, half of the animals of every group were sacrificed. The second half was exposed another 4 weeks before sacrifice. Organs were taken out for histopathological examinations and blood was collected for determination of serum levels of diverse hormons.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 848.5 MHz
ばく露時間: continuous 45 min/day, 5 days/week for 4 or 8 weeks
CDMA exposure
  • 電力: 30 W
  • SAR: 4 W/kg average over mass (whole body)
ばく露2: 848.5–1,950 MHz
ばく露時間: continuous 45 min/day, 5 days/week for 4 or 8 weeks
combined CDMA + WCDMA exposure
  • SAR: 4 W/kg average over mass (whole body) (2 W/kg for the CDMA signal and 2 W/kg for the WCDMA signal)
  • 電力: 30 W (for the CDMA signal)
  • 電力: 18 W (for the WCDMA signal)

General information

Rats were treated in the following three groups: i) sham exposure ii) exposure to CDMA iii) exposure to CDMA and WCDMA

ばく露1

主たる特性
周波数 848.5 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous 45 min/day, 5 days/week for 4 or 8 weeks
Additional information CDMA exposure
ばく露装置
ばく露の発生源/構造
  • patch antenna
チャンバの詳細 2295 mm x 2293 mm x 1470 mm reverberation chamber with 2.3 mm thick stainless steel walls
ばく露装置の詳細 eight 420 mm x 260 mm x 180 mm polycarbonate cages with 5 rats each placed on a table inside the exposure chamber; position of the cages changed daily
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 30 W - - - -
SAR 4 W/kg average over mass 計算値 whole body -

ばく露2

主たる特性
周波数 848.5–1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous 45 min/day, 5 days/week for 4 or 8 weeks
Additional information combined CDMA + WCDMA exposure
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 4 W/kg average over mass 計算値 whole body 2 W/kg for the CDMA signal and 2 W/kg for the WCDMA signal
電力 30 W - - - for the CDMA signal
電力 18 W - - - for the WCDMA signal

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

There was no difference in body weight among the sham, CDMA alone or combined exposed groups. Histopathological analysis of the organs was performed and no significant alterations were found.
After exposure to CDMA alone or simultaneous exposure to CDMA and WCDMA no alteration was found in serum melatonin levels in comparison to the sham exposed animals after 4 and after 8 weeks. Serum TSH concentration increased with age in both male and female rats, but no statistical significance between sham exposed and exposed animals was found. Serum triiodothyronine and thyroxine hormone levels of CDMA alone or combined exposed rats did not show any significant differences compared with sham exposed rats. Serum adrenocorticotropic hormone levels decreased with age in both male and female rats. However, CDMA alone or simultaneous combined exposure did not affect serum ACTH levels when compared with those of sham exposed rats. Sex hormone levels increased with age. CDMA alone or combined exposure of CDMA and WCDMA did not alter the serum level of sex hormones in comparison to the sham exposed group.
The authors summarize that neither CDMA nor a combination of CDMA and WCDMA exposure affected the rats' serum hormone level in this study.

研究の種別:

研究助成

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