研究のタイプ: 医学/生物学の研究 (experimental study)

[1.8GHzの無線周波電磁界にばく露したラットにおける抗酸化マーカの概日リズム] med./bio.

Circadian Rhythmicity of Antioxidant Markers in Rats Exposed to 1.8 GHz Radiofrequency Fields.

掲載誌: Int J Environ Res Public Health 2015; 12 (2): 2071-2087

この研究は、1.8GHzの無線周波RF電磁界電力密度201.7μW/cm2)にばく露したラットにおける概日リズムメラトニン(Mel)、グルタチオンペルオキシダーゼGSH-Px)、スーパーオキシドジスムターゼ(SOD)の血中濃度)の変化を調べた。ラットは7群(各n=6)に分け、対照群擬似ばく露)を除く6群は、グリニッジ時間の3時、7時、11時、15時、19時、23時からそれぞれ2時間のばく露を毎日32日間行った。最終日のばく露終了後から、4時間ごとに6回、全てのラットで採血を行った。その結果、RFばく露群のMel、GSH-Px、SODの概日リズムは、擬似ばく露群のものよりシフトした;23時および3時に開始したばく露では、Mel、GSH-Px、SODのレベルが有意に低下した、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 1.8 GHz electromagnetic field on the circadian concentration of melatonin, superoxide dismutase and glutathione peroxidase should be investigated.

詳細情報

The rats were divided into seven groups (n=6 each): daily exposure to the electromagnetic field from 3 to 5 h (group 1), 7 to 9 h (group 2), 11 to 13 h (group 3), 15 to 17 h (group 4), 19 to 21 h (group 5) and 23 to 1 h GMT (Greenwich Mean Time) on the next day (group 6) and sham exposure over 24 h/day (group 7) for 32 days. Subsequently to the last exposure period, blood samples were collected from each rat at 5, 9, 13, 17, 21 h and 1 h GMT on the following day.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.8 GHz
Modulation type: CW
ばく露時間: continuous for 2 h/day for 32 days

ばく露1

主たる特性
周波数 1.8 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 2 h/day for 32 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
チャンバの詳細 six animals per cage (466 Œ 315 Œ 210 mm)
ばく露装置の詳細 antenna was placed under a table to produce a vertical electromagnetic field in a shielded room; cage was placed on table, roof was hitched with microwave absorbing materials to avoid reflection; all animal handlings during the dark cycle were carried out using a dim red light (0.1 lux)
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 201.7 µW/cm² - 測定値 - -
SAR 0.05653 W/kg mean 計算値 whole body -
電力密度 0.001327 W/m² - - - input power density

Reference articles

  • Lopez-Martin F et al. (2008): [900MHzのGSM定在波の小動物での吸収電力の測定のための実験装置:Picrotoxin処理されたラットへの適用例]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Analysis of the circadian concentrations of the investigated parameters in the sham exposure revealed that there was an independent circadian rhythm in concentration for each parameter.
Significant decreases of the circadian concentration of the parameters were found in all groups compared to the sham exposure, with the most profound and consistent decreases in groups 1 and 6 for melatonin, and in group 1 for superoxide dismutase and glutathione peroxidase. Moreover, the daily mean concentration of all parameters was decreased, most distinctly in groups 1 and 6.
The authors conclude that exposure of rats to a 1.8 GHz electromagnetic field can decrease the circadian concentration as well as the daily mean concentration of melatonin, superoxide dismutase and glutathione peroxidase.

研究の種別:

研究助成

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