この研究は、マウス上皮におけるオルニチンデカルボキシラーゼ（ODC）およびポリアミンに対する磁界（MF）および模擬的太陽放射（SSR）の影響を調べた。その結果、慢性ばく露においては、SSR単独ばく露群との比較において、MFとSSRの組み合わせばく露群では、ODC活性またはポリアミンに対する持続的影響を引き起こさなかった；急性24時間ばく露においては、100 μTのMFばく露群で、プトレシン上昇およびODC活性低下が観察された；SSR急性24時間ばく露では、最小紅斑ドース（MED）の２倍のレベルでの単回ばく露で、影響は見られなかった、と報告している。
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The effects of an acute and chronic exposure of mice to a 50 Hz magnetic field on the epidermal level of polyamines and ornithine decarboxylase enzyme activity should be investigated.
The level of polyamines is increased in cancerous tissues and ornithine decarboxylase generates polyamines, so these parameters were used as markers for skin tumorigenesis. Tumor data of the same study was published elsewhere (Kumlin et al. 1998).
Transgenic K2 mice, which show a 30-50 fold higher ornithine decarboxylase enzyme activity compared to wild type mice, were used together with wild type mice.
For acute exposure experiments, the following groups with wild type and transgenic mice each were used (n=6 each): 1) exposure to UV radiation, 2) exposure to the magnetic field, 3) sham exposure. For chronic exposure experiments, further groups with wild type and transgenic mice each were used (n=10 each): 4) exposure to UV radiation, 5) exposure to UV radiation and continuous magnetic field , 6) exposure to UV and intermittent magnetic field and 7) sham exposure.
UV exposure groups received a single dose of 400 J/m² during acute exposure (group 1) and 200 J/m² for 35 min three times per week, respectively, during chronic exposure conditions (groups 4-6)
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 24 h |
| Additional information | acute exposure |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | polycarbonate cages |
| ばく露装置の詳細 | temperature and relative humidity were 23 ± 1°C and 50 ± 15%, respectively |
| Sham exposure | A sham exposure was conducted. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 100 µT | - | - | - | - |
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 10.5 months |
| Additional information | continous chronic exposure |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | - | - | - | - | not stated |
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | intermittend for 10.5 months |
| Additional information | intermittend chronic exposure with various MF intensities |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
In the acute exposure, a significant increase of the putrescine and spermidine levels was observed in transgenic mice exposed to the magnetic field (group 2) compared to sham exposed mice. In the same group, a significant decrease of the ornithine decarboxylase enzyme activity was spotted in transgenic mice compared to sham exposed mice. In wild type mice, no significant differences were found between the groups.
In wild type mice chronically exposed to UV radiation (group 4), a significant increase of the spermidine and spermine levels and a significant decrease of the putrescine level was observed compared to sham exposed mice. In transgenic mice, no significant differences were found between the groups. Moreover, no significant differences were found between groups co-exposed to UV radiation and a magnetic field (groups 5 and 6) and exposure to UV radiation alone.
The authors conclude that an acute exposure of mice to a 50 Hz magnetic field could affect the epidermal level of polyamines and ornithine decarboxylase enzyme activity and thus augment tumorigenesis.
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