研究のタイプ: 医学/生物学の研究 (experimental study)

[AKR/Jメスマウスのリンパ腫の生存率と自然発達に対するGSM変調900 MHz電磁界の影響はない] med./bio.

No effects of GSM-modulated 900 MHz electromagnetic fields on survival rate and spontaneous development of lymphoma in female AKR/J mice.

掲載誌: BMC Cancer 2004; 4: 77

携帯電話基地局などからの電磁界がんをプロモートすることをいくつかの報告書は伝えている。そこで、900Hz電磁界ばく露がAKR/Jマウスのリンパ腫発展に影響を与えるか調べた。方法:320匹のメスマウスを擬似ばく露ばく露(それぞれ160匹)として、平均の全身SARが0.4W/kgで、毎日24時間で1週当たり7日間900Hz電磁界ばく露させた。動物は日々、視覚的にチェックし、1周毎に体重をはかった。6カ月令で始め、1ヶ月毎に血液サンプルを採取した。疾病の兆候が見られた動物、または約46週間令で解剖した。電磁界ばく露は体重増加に大きな影響があった。ばく露群で大きかったが、生存率リンパ腫発生率は両群で違いはなかった。このようなことから、900MHz電磁界リンパ腫の重要なリスク要因だとする仮説は支持できない。

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研究目的(著者による)

To study whether 900 MHz electromagnetic field exposure influences lymphoma development in a mouse strain that is genetically predisposed to this disease: The AKR/J mice genome carries a virus, which leads within one year to spontaneous development of thymic lymphoblastic lymphoma.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for about 40 weeks
  • 電力: 35 W average over time
  • SAR: 0.4 W/kg mean (whole body)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for about 40 weeks
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Additional information

Synthetic GSM modulation pulse pattern and frequency spectrum simulating a typical GSM scenario, combining the emissions from a base station (downlink) with those from a mobile phone in DTX operation mode (uplink), thus including 2 Hz, 8 Hz, 217 Hz, and 1733 Hz frequency components.

ばく露装置
ばく露の発生源/構造
チャンバの詳細 Both waveguides (exposure and sham-exposure) of 4 m diameter and 17 cm vertical plate distance were placed within the same room and carried up to 24 cages measuring 425 mm Œ 265 mm Œ 160 mm (L Œ W Œ H) each of them housing 6-7 mice. The cage area was covered with trapezoidal lids (3 cages per opening) with wire mesh. At the outer boundaries of the units, absorbers were installed.
ばく露装置の詳細 A modulated signal generator and an amplifier were connected to the cone antenna of one unit (and also the presence of the field was monitored continuously) via a "black box" so that it could not be seen which group of animals was exposed (blind design).
Additional information Because the plate distance of the radial waveguide had to be chosen larger than half the wavelength due to the regulated height of the cages, special modifications of the fundamental geometry had to be performed to obtain only the fundamental TEM-mode and avoid the propagation of the unwanted higher order modes.
パラメータ
測定量 種別 Method Mass 備考
電力 35 W average over time - - -
SAR 0.4 W/kg mean 計算値 whole body -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 脳/腫瘍
  • spleen, thymus, lymph nodes, liver, kidney, lung
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Electromagnetic field exposure had a significant effect on body weight gain, with higher values in exposed than in sham-exposed mice. Survival rate and lymphoma incidence did not differ between exposed and sham-exposed mice. These results do not support the hypothesis that exposure to 900 MHz electromagnetic fields is a significant risk factor for developing lymphoma in a genetically predisposed species.

研究の種別:

研究助成

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