研究のタイプ: 医学／生物学の研究 (experimental study)

[UMTS変調無線周波数電磁界に慢性ばく露したマウスにおけるリンパ腫発生] med./bio.

Lymphoma Development in Mice Chronically Exposed to UMTS-Modulated Radiofrequency Electromagnetic Fields

著者: Sommer AM, Bitz AK, Streckert J, Hansen VW, Lerchl A
掲載誌: Radiat Res 2007; 168 (1): 72-80
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【目的】UMTS(ユニバーサル・モバイル・テレコミュニケーション・システム)の電磁界への慢性ばく露がリンパ腫動物モデル(AKR/Jマウス)のリンパ腫発生に影響を及ぼすか否かを調べること。【方法】拘束無しのマウスは、普及しているUMTS試験信号(24時間/日、7日/週、0.4W/kg SAR)に対するばく露(n＝160)または擬似ばく露(n＝160)を同一のじばく露システムで慢性的に与えられた。さらに、30匹のケージ対照群を用意した。マウスは、毎日、目視チェックし、毎週、体重測定とリンパ節の腫脹検出のための触診を行った。生後6カ月からは、2週間毎に血液サンプルを尻尾から採取し、白血球像検査とヘマトクリット値測定を行った。見るからに病気のマウスや生後43週を過ぎたマウスは安楽死させ、転移性浸潤やリンパ腫型を組織切片で調べた。実験は盲検式で行われた。【結果】ケージ対照群は放射導波管内に置かれたマウスよりも著しく成長速度が低かった。病気マウスの数、平均生存時間、病気の重症度コードは二つの実験グループ間で違いはなかった。【結論】データはばく露による悪影響はないことを示し、GSM EMFにばく露したAKR/Jマウスにおける以前の研究知見を裏付けた。

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研究目的（著者による）

To study whether chronic exposure to UMTS electromagnetic fields influences the development of lymphoma in a lymphoma animal model, the AKR/J mouse. The AKR/J mice genome carries a virus, which leads within one year to spontaneous development of thymic lymphoblastic lymphoma.

詳細情報

Mice were chronically sham exposed (n = 160) or exposed (n = 160). 30 animals were kept as cage controls.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.966 GHz
ばく露時間: almost continuous for up to 248 days
  • SAR: 0.4 W/kg mean (whole body) (±50%)

ばく露1

主たる特性
周波数 1.966 GHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 almost continuous for up to 248 days
Modulation
Modulation type cf. additional information
Additional information

generic UMTS test signal (1-min periodical) [Ndoumbe Mbonjo Mbonjo et al., 2004]
ばく露装置
ばく露の発生源／構造
チャンバの詳細 Animals were housed in groups of six to seven in polycarbonate cages (W 40 x L 25 x H 7 cm) with no metal parts. They were RF or sham exposed in the same room as the cage controls in two identical radial waveguides. The waveguides were 4 m in diameter with a vertical plate distance of 8 cm in the region of the cages and below 6 cm toward the center to produce a well-defined field distribution. RF-absorbers were installed at the outer boundaries of the units to reduce reflections and standing waves.
ばく露装置の詳細 Twenty-four cages per unit were placed at an equal distance from the center and covered with trapezoidal lids (three cages per opening) with wire mesh. The signal was connected to the cone antenna of one unit via a black box (blind design).
Sham exposure A sham exposure was conducted.
Additional information Animals were exposed 24 h per day with the exception of the time during which they were weighed and palpated and while the cages were cleaned. The waveguides were slightly overmoded with H = 0.525 λ. To prevent additional modes caused by field scattering by the mice, metal rip structures with a height and width of 2 cm were attached to the upper and lower plate between adjacent cages.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.4 W/kg mean 計算値 whole body ±50%
Additional parameter details

The overall spatial variation of the field in the cage regions was ±17.7%. The standard deviation of the mean whole-body SAR was ±50%.

測定および計算の詳細

Field measurements and numerical dosimetry were performed using the same methods as described in [Sommer et al., 2004].

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 免疫系
  • 脳／腫瘍
  • spleen, thymus, lymph nodes, liver, lung
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The data did not show any significant effect of chronic exposure to an UMTS signal on body weight gain or lymphoma incidence. Malignancy of the lymphomas was also not affected in these mice, which are genetically predisposed to this disease.

研究の種別:

研究助成

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