この実験研究は、若年（6週齢）および中年（12月齢）のラットのグリア原線維酸性たんぱく質（GFAP）発現に対する携帯電話のGSM信号（900 MHz；SAR = 6W/kg；15分間ばく露1回）ばく露の影響を調べた。調べた影響評価項目は、脳のインターロイキン（IL）-1β、IL-6、コルチコステロンの血中レベル、感情記憶である。その結果、前回公表した結果に反し、GSM信号の急性ばく露は星状グリア細胞の活性化を引き起こさなかったが、中年ラット群において嗅球のIL-1β上昇と文脈的感情記憶の増強が、また若年ラット群におい血中コルチコステロンレベルの上昇が引き起こされた等々を報告している。
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To assess glial fibrillary acidic protein (GFAP) levels in the brain of six week-old and twelve month-old rats, after exposure to GSM 900 MHz. Also interleukin expression and plasma levels of corticosterone and the emotional memory were examined.
For both ages rats were randomly assigned to either an exposure group or a sham exposure group (n=8-9 per group). On the first day of the experiment the rats were subjected to a fear conditioning training. After 48 hours they were exposed to an GSM signal for 15 minutes and tested for the sound memory. After additional 48 hours, contextual memory was tested and immediately followed by sacrifice.
Additionally, twelve control groups (n=6 per group) with six week-old rats were assigned which were sacrificed 30 minutes, 5 hours or 24 hours following (a) daily handling (cage control), (b) a single, 15 minutes, 6 W/kg exposure, (c) a single, 15 minutes sham exposure or (d) a 15 minutes sham exposure followed by a fear conditioning session.
Modulation type: pulsed
ばく露時間: continuous for 15 min
|ばく露時間||continuous for 15 min|
|Duty cycle||12.5 %|
|Repetition frequency||217 Hz|
|ばく露装置の詳細||animal placed in a Plexiglas rocket capped with a truncated cone; rocket body lined with air holes; loop antenna fixed to the rocket's cap|
|Sham exposure||A sham exposure was conducted.|
Acute GSM 900 MHz exposure did not alter the level of glial fibrillary acidic protein in the brain of rats.
An increase in IL-1ß in the olfactory bulb in exposed 12 month-old rats was found in comparison to 6 week-old rats and sham exposed ones. Additionally, an increased corticosterone level in 6 week-old exposed rats and an enhanced emotional memory in 12 month-old exposed rats was found in comparison to sham exposed rats.
The authors concluded that the data showed an age-dependent response to GSM exposure in neuro-immunity, stress and behavioural parameters.