研究のタイプ: 医学/生物学の研究 (experimental study)

[幼若ウサギの血液化学および酸化ストレスに対する出生の前と後のGSM様無線周波ばく露の影響:実験研究] med./bio.

Effects of Prenatal and Postnatal Exposure to GSM-Like Radiofrequency on Blood Chemistry and Oxidative Stress in Infant Rabbits, an Experimental Study.

掲載誌: Cell Biochem Biophys 2013; 67 (2): 743-751

この研究は、幼若ウサギの血液化学および酸化ストレスに対する1800MHzGSM様無線周波電磁界(RFR)への出生前と出生後のばく露の影響を調べた。合計72匹のニュージーランド白ウサギ(雌雄各36匹、1月齢)を雌雄各9匹計18匹ずつの4群に分けた:1) 擬似ばく露群、2) 出生前ばく露群(妊娠15日目から22日目までの間の7日間、1日15分間RFRばく露)、3) 出生後ばく露群(1月齢に達した時点から1日15分間RFRばく露開始し、雄は14日間、雌は7日間継続)、4) 出生前後ばく露群(第2、3群と同じ条件で両方の時期にばく露)。RFRは、矩形波パルス(繰り返し周波数217Hz、デューティサイクル1:8)で振幅変調された信号で、ばく露時の出力は0.1Wとしているが、ウサギの全身ばく露評価は記述されていない。結果として、RFRにより雌雄のウサギの血清中の脂質過酸化レベルが変化した;雌雄で異なる血液化学のパラメータが変化を受けた、と報告している。

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研究目的(著者による)

To investigate the potential hazardous effects of prenatal and/or postnatal exposure to a GSM-like radiofrequency field on the blood chemistry and lipid peroxidation levels of infant rabbits.

詳細情報

Pregnant rabbits were sham exposed (n=9) or exposed (n=9). After birth, 72 newborn were divided into four groups: 1.) sham exposure (control group), 2.) prenatal exposure, 3.) postnatal exposure and 4.) prenatal and postnatal exposure. Postnatal exposure started at an age of 1 month. During postnatal exposure, female infants were exposed for 7 days, whereas male infants were exposed for 14 days. The day after the last exposure, rabbits were killed and examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: 15 min/day for 7 days in pregnant animals (between 15th and 22nd day of gestation), for 7 days in female infants and for 14 days in male infants
  • 電力: 0.1 W maximum (applied output power)

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 15 min/day for 7 days in pregnant animals (between 15th and 22nd day of gestation), for 7 days in female infants and for 14 days in male infants
Modulation
Modulation type pulsed
Pulse width 576 ms
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
ばく露装置
ばく露装置の詳細 An RFR generator provided 20 dBm (0.1 W) power during the exposure period.
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 0.1 W maximum - - applied output power

Reference articles

  • Guler G et al. (2012): [雌雄の幼若ウサギにおけるDNA及び脂質のダメージに対する無線周波放射の影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

For infant female rabbits: There was no difference in the levels of cholesterol, uric acid, creatin kinase, creatine kinase-myocardial band isoenzyme and albumin. The level of gamma-glutamyl transpeptidase was significantly decreased in the groups with postnatal exposure compared to the control group. In the prenatal exposed group, the level of aspartate aminotransferase was significantly increased when compared to the control group. The level of alanine transaminase was significantly increased in the group with prenatal exposure and in the group with postnatal exposure in comparison to the control. In all exposure groups, the total protein content was significantly increased, while the level of glucose and the level of urea were significantly decreased compared to the control group. The amount of lipid peroxidation was significantly increased in the prenatal exposure group compared to the control group.
For infant male rabbits: There was no difference in the levels of cholesterol, urea, creatin kinase, creatine kinase-myocardial band isoenzyme, gamma-glutamyl transpeptidase, total protein and glucose. In all exposure groups, the levels of creatinine and albumin were significantly increased, while the level of gamma-glutamyl transpeptidase was significantly decreased compared to the control group. In both postnatal exposed groups, the level of uric acid was significantly increased when compared to the control. The level of alanine transaminase was significantly increased in the prenatal exposed group in comparison to he control group. The amount of lipid peroxidation was significantly increased in the prenatal exposure group compared to the control group.
(Remark EMF-Portal: Results taken from tables, sometimes variations in running text)
The authors conclude that exposure to a GSM-like radiofrequency field may lead to oxidative stress and changes on some blood chemistry parameters.

研究の種別:

研究助成

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