研究のタイプ: 医学/生物学の研究 (experimental study)

[妊娠/非妊娠ウサギ、および新生仔の肝臓のDNAと脂質の酸化的損傷に対する1800 MHz GSM類似信号の影響] med./bio.

The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in nonpregnant, pregnant, and newly born rabbits.

掲載誌: Cell Biochem Biophys 2010; 56 (1): 39-47

この実験研究は、1800 MHz GSM様無線周波数(RF電磁界全身ばく露(15 分/日、1週間)した非妊娠妊娠ニュージーランド・ホワイトラビットおよびその新生仔の肝臓酸化的DNA損傷および脂質過酸化レベルを評価した。妊娠/非妊娠ウサギ(各18匹)をそれぞれ9匹のばく露群と対照群に分け、妊娠ウサギからの新生仔は親のばく露、非ばく露(対照)によって区別した。1800 MHz GSM様電磁界は217Hzでパルス変調デューティサイクル1:8)した信号であり、出力は0.1W。ホーンアンテナ開口部に置いたケージに位置で測定した電界強度は14 ± 0.5 V/mであった。その結果、妊娠・非妊娠ばく露群は非妊娠対照群に比べ、マロンジアルデヒドMDA)とキシレノールオレンジ(FOX)レベルにおける第一鉄酸化が有意に上昇し(P<0.05、Mann-Whitney)、非ばく露群の新生仔では対照群の新生仔に比べ、肝臓FOXレベルが有意に上昇した(P<0.05、Mann-Whitney)と報告している。

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研究目的(著者による)

To study the possible biological effects of 1800 MHz GSM-like radiofrequency exposure on liver oxidative DNA damage and lipid peroxidation levels in non-pregnant and pregnant rabbits, and in their newborns.

詳細情報

18 non-pregnant and 18 pregnant rabbits were divided into four groups which were composed of nine rabbits: 1) non-pregnant control, 2) non-pregnant exposed rabbits, 3) pregnant control, 4) pregnant exposed animals. Newborns of the pregnant rabbits were also divided into two groups: 5) nine newborns of group 3 and 6) nine newborns of group 4 (intrauterine exposure during gestational period of day 15-22).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 min/day on 7 days

General information

animals were treated in six groups: i) non-pregnant control ii) non-pregnant exposed iii) pregnant control iv) pregnant exposed v) newborns of group iii) vi) newborns of gruop iv)

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min/day on 7 days
Modulation
Modulation type pulsed
Pulse width 0.576 ms
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 horn antenna placed above the cage in a shielded room
パラメータ
測定量 種別 Method Mass 備考
電力 0.1 W - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • liver
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were found in liver 8-hydroxy-2-deoxyguanosine levels of exposure groups (group 2 and 4) compared to the controls (group 1 and 3). However, in exposure groups malondialdehyde level and lipid peroxidation (ferrous ion oxidation) levels were increased compared to group 1. However, no significant difference was found in malondialdehyde level of group 4 (pregnant exposed) with respect to group 3 (pregnant control).
Remark EMF-Portal: Lipid peroxidation level of group 4 (pregnant, exposed) was not statistically significant different compared to group 1 (non-pregnant, control). Compared to group 3 (pregnant, control) the level of group 4 was statistically significant decreased.
No significant differences were found in liver tissue of 8-hydroxy-2-deoxyguanosine and malondialdehyde levels between the newborn groups (group 6 and group 5) while lipid peroxidation (ferrous ion oxidation) was significantly increased in group 6 with respect to group 5.
The authors conclude that whole body exposure to 1800 MHz GSM-like radiofrequency may lead to oxidative damage.

研究の種別:

研究助成

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