この実験研究は、1800 MHz GSM様無線周波数（RF）電磁界に全身ばく露（15 分/日、1週間）した非妊娠、妊娠ニュージーランド・ホワイトラビットおよびその新生仔の肝臓の酸化的DNA損傷および脂質過酸化レベルを評価した。妊娠／非妊娠ウサギ（各18匹）をそれぞれ9匹のばく露群と対照群に分け、妊娠ウサギからの新生仔は親のばく露、非ばく露（対照）によって区別した。1800 MHz GSM様電磁界は217Hzでパルス変調（デューティサイクル1:8）した信号であり、出力は0.1W。ホーンアンテナ開口部に置いたケージに位置で測定した電界強度は14 ± 0.5 V/mであった。その結果、妊娠・非妊娠のばく露群は非妊娠対照群に比べ、マロンジアルデヒド（MDA）とキシレノールオレンジ（FOX）レベルにおける第一鉄酸化が有意に上昇し（P<0.05、Mann-Whitney）、非ばく露群の新生仔では対照群の新生仔に比べ、肝臓FOXレベルが有意に上昇した（P<0.05、Mann-Whitney）と報告している。
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To study the possible biological effects of 1800 MHz GSM-like radiofrequency exposure on liver oxidative DNA damage and lipid peroxidation levels in non-pregnant and pregnant rabbits, and in their newborns.
18 non-pregnant and 18 pregnant rabbits were divided into four groups which were composed of nine rabbits: 1) non-pregnant control, 2) non-pregnant exposed rabbits, 3) pregnant control, 4) pregnant exposed animals. Newborns of the pregnant rabbits were also divided into two groups: 5) nine newborns of group 3 and 6) nine newborns of group 4 (intrauterine exposure during gestational period of day 15-22).
Modulation type: pulsed
ばく露時間: continuous for 15 min/day on 7 days
animals were treated in six groups: i) non-pregnant control ii) non-pregnant exposed iii) pregnant control iv) pregnant exposed v) newborns of group iii) vi) newborns of gruop iv)
|ばく露時間||continuous for 15 min/day on 7 days|
|Pulse width||0.576 ms|
|Duty cycle||12.5 %|
|Repetition frequency||217 Hz|
|ばく露装置の詳細||horn antenna placed above the cage in a shielded room|
No significant differences were found in liver 8-hydroxy-2-deoxyguanosine levels of exposure groups (group 2 and 4) compared to the controls (group 1 and 3). However, in exposure groups malondialdehyde level and lipid peroxidation (ferrous ion oxidation) levels were increased compared to group 1. However, no significant difference was found in malondialdehyde level of group 4 (pregnant exposed) with respect to group 3 (pregnant control).
Remark EMF-Portal: Lipid peroxidation level of group 4 (pregnant, exposed) was not statistically significant different compared to group 1 (non-pregnant, control). Compared to group 3 (pregnant, control) the level of group 4 was statistically significant decreased.
No significant differences were found in liver tissue of 8-hydroxy-2-deoxyguanosine and malondialdehyde levels between the newborn groups (group 6 and group 5) while lipid peroxidation (ferrous ion oxidation) was significantly increased in group 6 with respect to group 5.
The authors conclude that whole body exposure to 1800 MHz GSM-like radiofrequency may lead to oxidative damage.