研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒト乳房線維芽細胞のミトコンドリア膜電位、アポトーシス活性および細胞生存率に対する2.1GHzマイクロ波放射の影響の研究] med./bio.

Investigation of the effects of 2.1 GHz microwave radiation on mitochondrial membrane potential (DeltaPsim), apoptotic activity and cell viability in human breast fibroblast cells.

掲載誌: Cell Biochem Biophys 2013; 67 (3): 1371-1378

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研究目的(著者による)

To examine the effects of exposure to a Wideband Code Division Multiple Access signal (W-CDMA) on cell viability and apoptosis in human breast fibroblasts.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.1 GHz
ばく露時間: continuous for 4 or 24 hours

ばく露1

主たる特性
周波数 2.1 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 4 or 24 hours
ばく露装置
ばく露の発生源/構造
チャンバの詳細 cells were grown in 24-well culture plates in humidified cell incubator at 37°C under 5 % CO2 and 95 % air
ばく露装置の詳細 24 well-plate was placed above the transmitting antenna
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.142 mW/cm² - - - -
SAR 0.607 W/kg spatial average 計算値 10 g -
電力 1 W - - - input power

Reference articles

  • Zeni O et al. (2012): [1950 MHz(UMTS)の無線周波放射は神経様PC12細胞の主要な影響評価項目に影響しない]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In the exposed cell cultures, the cell viability was significantly decreased compared to the corresponding sham exposure. Annexin V and propidium iodide staining showed a significantly increased apoptosis rate in exposed cell cultures in comparison to the sham exposed cell cultures. However, no significant changes between exposed and sham exposed cell cultures occurred regarding the level of tumor necrosis factor receptor. The mitochondrial membrane potential was significantly decreased in exposed cell cultures compared to sham exposure.
The data indicate that exposure of human breast fibroblasts to a W-CDMA signal could reduce the cell viability and induce apoptosis via a mitochondrial pathway.

研究の種別:

研究助成

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