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To examine the effects of exposure to a Wideband Code Division Multiple Access signal (W-CDMA) on cell viability and apoptosis in human breast fibroblasts.
|ばく露時間||continuous for 4 or 24 hours|
|チャンバの詳細||cells were grown in 24-well culture plates in humidified cell incubator at 37°C under 5 % CO2 and 95 % air|
|ばく露装置の詳細||24 well-plate was placed above the transmitting antenna|
|Sham exposure||A sham exposure was conducted.|
In the exposed cell cultures, the cell viability was significantly decreased compared to the corresponding sham exposure. Annexin V and propidium iodide staining showed a significantly increased apoptosis rate in exposed cell cultures in comparison to the sham exposed cell cultures. However, no significant changes between exposed and sham exposed cell cultures occurred regarding the level of tumor necrosis factor receptor. The mitochondrial membrane potential was significantly decreased in exposed cell cultures compared to sham exposure.
The data indicate that exposure of human breast fibroblasts to a W-CDMA signal could reduce the cell viability and induce apoptosis via a mitochondrial pathway.