研究のタイプ: 疫学研究 (observational study)

[高齢のメキシコ系アメリカ人における重度認知機能障害と超低周波磁界の職業ばく露] epidem.

Severe cognitive dysfunction and occupational extremely low frequency magnetic field exposure among elderly Mexican Americans.

掲載誌: Br J Med Med Res 2014; 4 (8): 1641-1662

この研究は、高齢者の疫学研究のためのヒスパニック定住集団(H-EPESE)第1相研究で登録された年齢65歳以上のメキシコ系アメリカ人3050人を対象にした人口ベース症例対照研究である。全員のミニ精神状態試験(MMSE)スコア、主な職歴などのデータを収集した。MMSEスコアが10点を下回る人を重度認知機能障害と定義した。職業的な磁界MFばく露は、これまでの研究方法を用いて定義した。その結果、単一変数の分析でのオッズ比OR)は、MF高ばく露職業群で3.4(95%信頼区間:1.3-8.9)、高および中ばく露職業群を合計した場合1.7(同:0.7-4.1)であった(両群合わせても重度認知障害者数は数名程度であった);多変量の主効果モデルでの分析でも同様の結果であった、などを報告している。

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研究の目的(著者による)

A population-based cohort study was conducted in the USA to investigate the association between severe cognitive dysfunction and occupational extremely low frequency magnetic field exposure among elderly Mexican Americans.

詳細情報

A Mini-Mental State Exam score below 10 was used to define cognitive dysfunction.

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (オッズ比(OR))

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 average occupational magnetic field exposure < 0.2 or intermittently < 1 µT: low
集団 2 average occupational magnetic field exposure between 0.2 and 1 µT or intermittently > 1 µT: medium
集団 3 average occupational magnetic field exposure > 1 µT or intermittently > 10 µT: high

調査対象集団

調査規模

タイプ
参加者 3,050
参加率 85 %
評価可能 2,844
統計学的分析方法:

結論(著者による)

Overall 91.8% of the study participants hat a low occupational magnetic field exposure, 4.7% a medium exposure and 3.5% a high exposure. About 1.7% of 2873 subjects with a Mini-Mental State Exam had a MMSE score below 10.
Significant increased risks for severe cognitive dysfunction were observed for high (group 2: OR 3.4, CI 1.3-8.9) and for 'medium or high' occupational magnetic field exposure (groups 2 + 3: OR 1.7, CI 0.7-4.1). Interaction between occupational magnetic field exposure and other possible risk factors were investigated. The results showed that the interactions between 'medium or high' or high occupational MF exposure and smoking history or age group were statistically significant, depending upon whether two (65-74, 75+) or three (65-74, 75-84, 85+) age groups were considered, respectively.
The authors conclude that working in an occupation with high or 'medium or high' magnetic field exposure may increase the risk of severe cognitive dysfunction. Smoking and older age may increase the deleterious effect of occupational magnetic field exposure.

研究助成

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