研究のタイプ: 医学/生物学の研究 (experimental study)

[マウスの生殖能力に対するMg2+サイクロトロン周波数電磁界の影響] med./bio.

The Effect of Electromagnetic Fields with the Mg2+ Cyclotron Frequency on Mouse Reproductive Performance.

掲載誌: J Electromagn Anal 2016; 8 (3): 115-123

この研究は、Mg2+のサイクロトロン周波数(およそ60 Hz)の周波数の低レベル磁界(≅50 μT)への100日間の連続ばく露がマウスの生殖に及ぼす影響を調べた。雌4匹と雄1匹を1グループとして、ばく露群(4グループ)および対照(1グループ)で影響を比較した。その結果、ばく露群での1出産当たりの新生仔の数は、対照に比べ有意に低かった;各グループで平均した新生仔の11日齢での体重は、対照に比べ、ばく露群で有意に低かった;解剖後検査で、仔マウスでの軽度肝臓炎症所見、および母マウスでの心筋肥大発生率が対照に比べ、ばく露群で有意に高かった、と報告している。

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研究目的(著者による)

The effects of exposure of mice to a 60 Hz magnetic field on reproductive performance should be investigated.

詳細情報

The applied frequency (about 60 Hz) matches the cyclotron frequency of Mg2+. The authors hypothesized that this frequency would be likely to have an effect on reproduction performance, as Mg2+ plays an important role in cell division.
Mice were divided into 2 groups: exposure group (divided into 4 subgroups, each consisting of 4 female and 1 male mouse) and control group (4 female and 1 male mouse).
Blood samples of adult mice were taken after 100 days of exposure. Newborn mice were killed 11 days after birth and adults were killed after exposure for histological examinations.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous for 100 days

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 100 days
Additional information cyclotron frequency of Mg2+
ばく露装置
ばく露の発生源/構造
チャンバの詳細 cages made of polypropylene with ceilings made of a meshed stainless steel
ばく露装置の詳細 6 coils with a radius of 380 mm and which were spaced 380 mm apart in a Helmholtz configuration; the total length of the exposure space was 1.9 m; each of the coils was made of glass fiber, with copper wire windings wrapped within carbon fiber; each subgroup was housed in a single cage placed between the coils; environmental conditions were controlled, e.g., environmental temperature of 21°C ± 1°C and humidity between 40% and 70%
パラメータ
測定量 種別 Method Mass 備考
磁束密度 38 µT minimum 測定値 - -
磁束密度 47 µT maximum 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The average number of offspring per birth was significantly lower in exposed dams compared to the control group and a significantly lower average daily gain of body weight per mouse was observed in exposed pups compared to the control group 7 and 11 days after birth, resulting in a significant reduction of the average body weight per nest.
In hematological and biochemical analysis of the blood of adults, the only changes were a significantly reduced number neutrophils and lymphocytes in exposed mice compared to the control group.
Histopathological examinations revealed a significant increase in mild chronic hepatic inflammatory findings in the offspring and a significantly increased occurrence of myocardial hypertrophy in the dams of the exposure group compared to the control group. However, splenic follicular hyperplasia was significantly higher in the control group than in the exposure group.
The authors conclude that exposure of mice to a 60 Hz magnetic field might have a weak detrimental effect on reproductive performance.

研究の種別:

研究助成

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