研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話放射へのばく露後のマウス着床前胚の生存力評価] med./bio.

Survival assessment of mouse preimplantation embryos after exposure to cell phone radiation.

掲載誌: J Reprod Infertil 2016; 17 (3): 138-143

この研究は、マウスの着床前胚の品質および生存率に対する携帯電話放射EMF: 900-1800 MHz)へのばく露の影響を調べた。まず、雌雄各20匹の6週齢BALB/cマウスを対照群およびばく露群に割り当て、交尾の翌朝、各マウスから卵囊を摘出して接合体を取り出し培養した。対照群およびばく露群それぞれから得た2細胞期胚(各n=150)を対照群ばく露群として、ばく露群はCO2培養器(37℃)内での培養中に4時間/日、4日間のばく露を与えた。その結果、両群の胚盤胞期の胚生存率は同じであった;しかし、2細胞期での死亡胚の割合はEMFばく露群の方が対照群より有意に高かった;胚盤胞期の胚の生存力喪失(高品質な胚の割合低下)は、ばく露群で有意に増加した、と報告している。

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研究目的(著者による)

The effects of exposure of mice 2-cell-state embryos to a 900-1800 MHz electromagnetic field on embryonal development and cell viability should be investigated.

詳細情報

40 mice were mated and on the following day, zygotes were isolated and incubated for 5 hours. Afterwards, 2-cell-state embryos were divided into 2 groups (n=150 each): exposure group and control group.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900–1,800 MHz
ばく露時間: 30 minutes/day for 4 days
  • SAR: 0.683 W/kg minimum
  • SAR: 0.725 W/kg maximum

ばく露1

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 30 minutes/day for 4 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • Huawei Ascend y300
チャンバの詳細 incubator with 37°C and 5% CO2
ばく露装置の詳細 "cell phone was held horizontally and parallel to the zygotes culture medium inside the incubator while the bottom of the phone being placed 1 cm above the upper from the stage of incubator" (?); phone was kept in talk mode and the distance between the phone and embryos was > 10 cm
Additional information embryos of the control group were kept in an incubator without exposure to the cell phone
パラメータ
測定量 種別 Method Mass 備考
SAR 0.683 W/kg minimum - - -
SAR 0.725 W/kg maximum - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

At the 2-cell stage, the percentage of dead embryos was significantly increased in the exposure group compared to the control group. Moreover, the rate of dead cells was significantly increased in blastocysts from the exposure group compared to the control group.
The embryonal survival rate at the blastocyst stage did not show significant differences between both groups.
The authors conclude that exposure of mice 2-cell-state embryos to a 900-1800 MHz electromagnetic field has no detrimental effects on embryonal development but might decrease cell viability.

研究の種別:

研究助成

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