研究のタイプ: 医学/生物学の研究 (experimental study)

[低周波数電磁界への亜慢性ばく露後のラット甲状腺の形態生理学的状態] med./bio.

Morphophysiological status of rat thyroid gland after subchronic exposure to low frequency electromagnetic field.

掲載誌: Med Pregl 2001; 54 (3-4): 119-127

この研究は、Mill Hill系統のオスラット甲状腺に対する低周波電界および磁界の影響を調べた。周波数50 Hz、500 μTから50 μTへと減衰する磁界および10 V / mの電界へのばく露を、生後24時間から開始して、1日7時間、週5日で3ヶ月間継続した。結果として、ばく露終了後の甲状腺組織学的および立体学的分析により、ばく露群では、対照群に比べ、甲状腺濾胞の体積密度の増加、濾胞上皮の厚さの減少、内腔の濾胞内コロイド含有量の減少、甲状腺活性指標の低下、傍濾胞細胞の体積密度の増加、濾胞間結合組織の体積の減少および脱顆粒肥満細胞数の増加が明らかにされた;また、放射免疫学アッセイで測定された血清中の甲状腺ホルモン濃度については、ばく露群では、対照群に比べ、総T4および総T3の低下が明らかであった、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a magnetic and electric field (50 Hz) on the histology of the thyroid gland and thyroid hormone concentrations in the blood should be investigated.

詳細情報

The rats were divided into two groups: 1) exposure (n=12) and 2) sham exposure (n=11). Exposure started 24 hours after birth of rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 7 h/day, 5 days/week, for 3 months

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • electric field
  • magnetic field
ばく露時間 continuous for 7 h/day, 5 days/week, for 3 months
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 single coil of 2.5 mm thick wire placed on a wooden frame with 1320 turns; cages with animals were placed symmetrically on both sides of the coil
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 10 V/m - - - -
磁束密度 500 µT maximum - - at the cage's side near the coil
磁束密度 50 µT minimum - - at the cage's side opposite to the coil

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In histological analyses, the exposure group showed significant changes compared to the sham exposure group: increased volume density of thyroid follicles, decreased thickness of the follicular epithelium and intrafollicular colloid content, increased volume density of parafollicular cells, decreased volume of interfollicular connective tissue and increased number of degranulated mast cells.
No significant differences were observed in the concentrations of triiodothyronine and thyroxine concentrations in the blood between exposed animals an the sham exposure group, although a tendency towards smaller values in exposed animals was observed.
The authors conclude that exposure of rats to a magnetic and electric field (50 Hz) might cause alterations in the histology and function of the thyroid gland, which could be interpreted as a decrease of thyroid gland activity.

研究の種別:

研究助成

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