研究のタイプ: 医学/生物学の研究 (experimental study)

[低周波数電磁界への亜慢性ばく露後のラット甲状腺の形態生理学的状態] med./bio.

Morphophysiological status of rat thyroid gland after subchronic exposure to low frequency electromagnetic field.

掲載誌: Med Pregl 2001; 54 (3-4): 119-127

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研究目的(著者による)

The effects of exposure of rats to a magnetic and electric field (50 Hz) on the histology of the thyroid gland and thyroid hormone concentrations in the blood should be investigated.

詳細情報

The rats were divided into two groups: 1) exposure (n=12) and 2) sham exposure (n=11). Exposure started 24 hours after birth of rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 7 h/day, 5 days/week, for 3 months

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • electric field
  • magnetic field
ばく露時間 continuous for 7 h/day, 5 days/week, for 3 months
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 single coil of 2.5 mm thick wire placed on a wooden frame with 1320 turns; cages with animals were placed symmetrically on both sides of the coil
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 10 V/m - - - -
磁束密度 500 µT maximum - - at the cage's side near the coil
磁束密度 50 µT minimum - - at the cage's side opposite to the coil

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In histological analyses, the exposure group showed significant changes compared to the sham exposure group: increased volume density of thyroid follicles, decreased thickness of the follicular epithelium and intrafollicular colloid content, increased volume density of parafollicular cells, decreased volume of interfollicular connective tissue and increased number of degranulated mast cells.
No significant differences were observed in the concentrations of triiodothyronine and thyroxine concentrations in the blood between exposed animals an the sham exposure group, although a tendency towards smaller values in exposed animals was observed.
The authors conclude that exposure of rats to a magnetic and electric field (50 Hz) might cause alterations in the histology and function of the thyroid gland, which could be interpreted as a decrease of thyroid gland activity.

研究の種別:

研究助成

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