[インビボの60 Hz磁界がマウスの脳のモノアミン値に及ぼす効果] med./bio.

The effects of an acute or chronic exposure of mice to different 60 Hz magnetic fields on monoamine levels in the brain should be investigated.

Monoamines are neurotransmitters and neuromodulators and therefore important for the function of the brain.
The following groups were used: 1) exposure of C57BL mice to the magnetic field with 1 mT for 7 days (n=3), 2) exposure of ICR mice for 12 weeks (n=4), 3) exposure of 1-month-old SAMP8 mice for 6 h (n=4), 4) exposure of 3-month-old SAMP8 mice for 6 h (n=4), 5) exposure of 6-month-old SAMP8 mice for 6 h (n=4), 6) exposure of 9-month-old SAMP8 mice for 6 h (n=4) and 7) exposure of 12-month-old SAMP8 mice for 6 h (n=4). For each group, a separate control group with the same number of animals was used. Moreover, restrained ICR mice were exposed to a magnetic field at their heads with 8) 0.1 mT, 9) 0.33 mT or 10) 1 mT (n=6-15 each). A not-restrained and a restrained control group with the same number of animals were used for groups 8-10.

• 動物
• mouse/C57BL, ICR and SAMP8
• 全身
• 身体の一部: head

No significant changes could be observed in groups 1-7 compared to their respective control groups.
The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid were significantly increased in several brain regions in groups 8-10 compared to the not-restrained control group without showing a distinct trend. However, the restrained control group showed increased values in comparison to the not-restrained control group as well (remark EMF-Portal: result contradictory: abstract and discussion vs. result table).
The authors conclude that exposure of mice to a 60 Hz magnetic field might increase the stress caused by restraining and thus influence monoamine levels in the brain.