研究のタイプ: 医学/生物学の研究 (experimental study)

[マウス脳の抗酸化防御系への低周波磁界の影響:化学発光研究] med./bio.

Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study.

掲載誌: J Photochem Photobiol B 2004; 73 (1-2): 43-48

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研究目的(著者による)

The effects of exposure of mice to a 60 Hz magnetic field on oxidative stress and the antioxidative defense in the brain should be investigated.

詳細情報

Mice were divided into two groups (n=14 each): an exposure group and a sham exposure group.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: continuous for 3 hours

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 3 hours
ばく露装置
ばく露の発生源/構造
チャンバの詳細 cage made of non-magnetic material
ばく露装置の詳細 Helmholtz coils (1 m2, 100 turns of 1 mm copper wire) were embedded in an open wooden rectangular frame; each winding was split allowing the current to flow in the same sense through each half of the winding (field aiding); coils produced a MF in the horizontal direction at the center of the system
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1.2 mT effective value 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The amount of reactive oxygen species was not significantly different between the exposure and sham exposure group. However, lipid peroxidation and the superoxide dismutase enzyme activity were significantly increased in the exposure group compared to the sham exposure group.
The authors conclude that exposure of mice to a 60 Hz magnetic field could cause oxidative stress and deteriorate the antioxidative defense in the brain.

研究の種別:

研究助成

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