Study type: Medical/biological study (experimental study)

The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in nonpregnant, pregnant, and newly born rabbits. med./bio.

Published in: Cell Biochem Biophys 2010; 56 (1): 39-47

Aim of study (acc. to author)

To study the possible biological effects of 1800 MHz GSM-like radiofrequency exposure on liver oxidative DNA damage and lipid peroxidation levels in non-pregnant and pregnant rabbits, and in their newborns.

Background/further details

18 non-pregnant and 18 pregnant rabbits were divided into four groups which were composed of nine rabbits: 1) non-pregnant control, 2) non-pregnant exposed rabbits, 3) pregnant control, 4) pregnant exposed animals. Newborns of the pregnant rabbits were also divided into two groups: 5) nine newborns of group 3 and 6) nine newborns of group 4 (intrauterine exposure during gestational period of day 15-22).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 15 min/day on 7 days

General information

animals were treated in six groups: i) non-pregnant control ii) non-pregnant exposed iii) pregnant control iv) pregnant exposed v) newborns of group iii) vi) newborns of gruop iv)

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 15 min/day on 7 days
Modulation
Modulation type pulsed
Pulse width 0.576 ms
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
Exposure setup
Exposure source
Setup horn antenna placed above the cage in a shielded room
Parameters
Measurand Value Type Method Mass Remarks
power 0.1 W - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No significant differences were found in liver 8-hydroxy-2-deoxyguanosine levels of exposure groups (group 2 and 4) compared to the controls (group 1 and 3). However, in exposure groups malondialdehyde level and lipid peroxidation (ferrous ion oxidation) levels were increased compared to group 1. However, no significant difference was found in malondialdehyde level of group 4 (pregnant exposed) with respect to group 3 (pregnant control).
Remark EMF-Portal: Lipid peroxidation level of group 4 (pregnant, exposed) was not statistically significant different compared to group 1 (non-pregnant, control). Compared to group 3 (pregnant, control) the level of group 4 was statistically significant decreased.
No significant differences were found in liver tissue of 8-hydroxy-2-deoxyguanosine and malondialdehyde levels between the newborn groups (group 6 and group 5) while lipid peroxidation (ferrous ion oxidation) was significantly increased in group 6 with respect to group 5.
The authors conclude that whole body exposure to 1800 MHz GSM-like radiofrequency may lead to oxidative damage.

Study character:

Study funded by

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