Study type: Medical/biological study (experimental study)

Caffeic Acid Phenethyl Ester Modulates 1800 MHz Microwave-Induced Oxidative Stress in Rat Liver. med./bio.

Published in: Electromagn Biol Med 2005; 24 (2): 135-142

Aim of study (acc. to author)

To study the effects of microwaves on the liver oxidant/antioxidant system as well as the possible protective effects of CAPE on the liver toxicity induced by microwaves.

Background/further details

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. CAPE is found to be a potent free radical scavenger and antioxidant.
CAPE was injected for 30 days before exposure to microwaves. 29 rats were divided into three groups: control, microwave exposure and "microwave exposure + CAPE administration".



Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 1 h/day, for 30 days

Exposure 1

Main characteristics
Frequency 1,800 MHz
Exposure duration repeated daily exposure, 1 h/day, for 30 days
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
Chamber A special exposure device with five antennas was used.
Setup Rats were individually placed in ventilated round plastic tube cages (12 cm long x 5.5 cm in diameter) that were positioned in close contact above the antenna.
Sham exposure A sham exposure was conducted.
Additional info In control (sham) and RF-only exposed rats, an equal volume of isotonic saline solution was administered i.p. instead of CAPE.
Measurand Value Type Method Mass Remarks
power density 1 mW/cm² mean measured - ± 0.04 mW/cm²
SAR 2 W/kg peak value unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The activities of xanthine oxidase, catalase and level of lipid peroxidation increased in microwave exposed animals compared with the control group although xanthine oxidase and lipid peroxidation levels were decreased by "microwave exposure + CAPE administration".
The activities of superoxide dismutase and glutathione peroxidase decreased in the microwave exposed group compared with the control group. Their levels were increased by "microwave expsoure + CAPE administration".
The authors conclude that CAPE may prevent microwave-induced oxidative changes in liver by strengthening the antioxidant defense system, by reducing reactive oxygen species, and by increasing antioxidant enzyme activities.

Study character:

Study funded by

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