Study type: Medical/biological study (experimental study)

A novel antioxidant agent caffeic acid phenethyl ester prevents long-term mobile phone exposure-induced renal impairment in rat. Prognostic value of malondialdehyde, N-acetyl-beta-D-glucosaminidase and nitric oxide determination med./bio.

Published in: Mol Cell Biochem 2005; 277 (1-2): 73-80

Aim of study (acc. to author)

To study long-term applied 900 MHz emitting mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) and to investigate the role of CAPE (caffeic acid phenethyl ester) on kidney tissue against the possible electromagnetic irradiation-induced renal impairment in rats.

Background/further details

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. It was found to be a potent free radical scavenger and antioxidant.
ROS such as superoxide and nitric oxide may contribute to the pathophysiology of electromagnetic irradiation-induced renal impairment.



Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 30 min/day for 3 months
  • power: 2 W peak value
  • power density: 1.04 mW/cm² unspecified
  • SAR: 0.016 W/kg average over mass (whole body)
  • SAR: 4 W/kg maximum (unspecified)

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration repeated daily exposure, 30 min/day for 3 months
Modulation type pulsed
Exposure setup
Exposure source
Chamber A special exposure device with six exposure antennas was used. One exposure system consisted of a ventilated plastic tube cage (12 cm long x 5 cm in diameter) and a half-wave dipole antenna.
Setup The whole body of the rat was positioned in close contact above the antenna.
Additional info Rats were allocated to four groups: control (without stress and EMR), sham exposed, EMR exposed, and EMR exposed + CAPE treated. CAPE was injected i.p. daily immediately before exposure. Sham exposed rats received isotonic saline solution instead.
Measurand Value Type Method Mass Remarks
power 2 W peak value - - -
power density 1.04 mW/cm² unspecified measured - -
SAR 0.016 W/kg average over mass measured whole body -
SAR 4 W/kg maximum measured unspecified -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the electromagnetic field exposed group, while tissue malondialdehyde, nitric oxide levels and urinary NAG levels increased, the activities of superoxide dismutase, catalase, and glutathione peroxidase in renal tissue were reduced. CAPE treatment reversed these effects as well.
In conclusion, the data demonstrate the role of oxidative mechanisms in 900 MHz mobile phone-induced renal tissue damage. CAPE, via its free radical scavenging and antioxidant properties, ameliorates oxidative renal damage. These data strongly suggest that CAPE exhibits a protective effect on mobile phone-induced and free radical mediated oxidative renal impairment in rats.

Study character:

Study funded by

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