Home
Medical/biological study (experimental study)

The effect of prenatal exposure to 900-megahertz electromagnetic field on the 21-old-day rat testicle.

Published in: Reprod Toxicol 2013; 42: 203-209

Aim of study (acc. to author)

To investigate the effect of a prenatal exposure to a radiofrequency electromagnetic field on the testis of 21 day-old rats.
Background/further details: Six pregnant rats were divided into a cage control and an exposure group (n=3 per group). The groups were kept in different cages in the same room during the experiment except for exposure, which was performed in another room from the 13th to the 21st day of pregnancy. 10 male pups of each group were killed and examined at the 21st day after birth.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: 1 h/day from 13th to 21st day of pregnancy
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Charakteristic
Exposure duration 1 h/day from 13th to 21st day of pregnancy
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber rats were placed in a jar (30 cm * 42 cm * 52 cm) made of plexiglas for exposure, antenna was installed in the central region, approximately 11 cm inside the open surface of the jar
Additional info half-wave dipole antenna made from a 1 mm x 15 cm copper rod with the help of a coaxial cable
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 10 V/m mean measured - -
power density 0.265 W/m² - - - -
power 300 mW - estimated - output power
Reference articles
  • Sonmez OF et al. (2010): Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field.
  • Bas O et al. (2009): Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats.
  • Bas O et al. (2009): 900 MHz electromagnetic field exposure affects qualitative and quantitative features of hippocampal pyramidal cells in the adult female rat.
  • Odaci E et al. (2008): Effects of prenatal exposure to a 900 MHz electromagnetic field on the dentate gyrus of rats: a stereological and histopathological study.
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The prenatally exposed rats exhibited irregularities in the histopathological examination of the testis in comparison to those of the cage control: The diameter of the seminiferous tubules and the thickness of its epithelium were significantly decreased. Additionally, basal lamina seperation and immature germ cells were found in the lumen.
The apoptosis rate, lipid peroxidation and DNA damage were significantly increased in the exposure group compared to the cage control. No differences occurred regarding the weight of the testis.
The authors conclude that prenatal exposure to a radiofrequency electromagnetic field could have an adverse effect on the testis of 21 day-old rats.
Study character:

Study funded by

  • not stated/no funding

Related articles

  • Pandey N et al. (2017): Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice.
  • Tumkaya L et al. (2016): Mobile phone radiation during pubertal development has no effect on testicular histology in rats.
  • Turedi S et al. (2015): The effects of prenatal exposure to a 900-MHz electromagnetic field on the 21-day-old male rat heart.
  • Saygin M et al. (2015): Impact of L-carnitine and Selenium Treatment on Testicular Apoptosis in Rats Exposed to 2.45 GHz Microwave Energy.
  • Odaci E et al. (2015): Exposure to a 900 MHz electromagnetic field for 1 hour a day over 30 days does change the histopathology and biochemistry of the rat testis.
  • Sokolovic D et al. (2015): The Effects of Melatonin on Oxidative Stress Parameters and DNA Fragmentation in Testicular Tissue of Rats Exposed to Microwave Radiation.
  • Meena R et al. (2014): Therapeutic approaches of melatonin in microwave radiations-induced oxidative stress-mediated toxicity on male fertility pattern of Wistar rats.
  • Mugunthan N et al. (2014): Effects of long term exposure to a 2G cell phone radiation (900 - 1900 MHz) on mouse testis.
  • Kumar S et al. (2014): Effect of electromagnetic irradiation produced by 3G mobile phone on male rat reproductive system in a simulated scenario.
  • Ozorak A et al. (2013): Wi-Fi (2.45 GHz)- and Mobile Phone (900 and 1800 MHz)-Induced Risks on Oxidative Stress and Elements in Kidney and Testis of Rats During Pregnancy and the Development of Offspring.
  • Atasoy HI et al. (2013): Immunohistopathologic demonstration of deleterious effects on growing rat testes of radiofrequency waves emitted from conventional Wi-Fi devices.
  • Al-Damegh MA (2012): Rat testicular impairment induced by electromagnetic radiation from a conventional cellular telephone and the protective effects of the antioxidants vitamins C and E.
  • Guler G et al. (2012): The effect of radiofrequency radiation on DNA and lipid damage in female and male infant rabbits.
  • Ozlem Nisbet H et al. (2012): Effects of exposure to electromagnetic field (1.8/0.9 GHz) on testicular function and structure in growing rats.
  • Celik S et al. (2012): An evaluation of the effects of long-term cell phone use on the testes via light and electron microscope analysis.
  • Imai N et al. (2011): Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones.
  • Zeng L et al. (2011): MnSOD expression inhibited by electromagnetic pulse radiation in the rat testis.
  • Lee HJ et al. (2010): The lack of histological changes of CDMA cellular phone-based radio frequency on rat testis.
  • Ribeiro EP et al. (2007): Effects of subchronic exposure to radio frequency from a conventional cellular telephone on testicular function in adult rats.
  • Subbotina TI et al. (2006): Effect of low-intensity extremely high frequency radiation on reproductive function in wistar rats.