研究のタイプ: 医学/生物学の研究 (experimental study)

[環境非電離放射による細胞タンパクの変化. 1. 熱ショックタンパク] med./bio.

Changes in cellular proteins due to environmental non-ionizing radiation. I. Heat-shock proteins.

掲載誌: Electro Magnetobiol 2001; 20 (2): 141-152

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研究目的(著者による)

To study the effect of weak microwave fields on the amounts of heat-shock proteins in cell cultures at various temperatures (35, 37, and 40°C). To study the effect of heating only, the cells were placed in the field-free exposure incubator and were heated to the same and also to higher temperatures up to 42°C.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 960 MHz
Modulation type: pulsed
ばく露時間: continuous for 20 min

ばく露1

主たる特性
周波数 960 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 20 min
Modulation
Modulation type pulsed
Duty cycle 12 %
Repetition frequency 217 Hz
Pulse type rectangular
Additional information

simulated GSM

ばく露装置
ばく露の発生源/構造
チャンバの詳細 A TEM cell of 320 mm length and 160 mm TEM region was located in an incubator maintained at 35, 37, and 40 ± 0.1°C.
ばく露装置の詳細 A Petri dish containing 4 glass cover slips with cell cultures was placed in the TEM cell. A control dish was placed outside the TEM cell at a distance of 20 cm from the exposed dish.
Additional information Sham experiments were made with the TEM cell not powered. Effects of heating only (up to 42°C) were studied by placing the coverslips in a field-free incubator.
パラメータ
測定量 種別 Method Mass 備考
電界強度 17 mV/cm peak 計算値 - -
SAR 2.1 mW/kg unspecified 計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

At both 35 and 37°C, higher amounts of Hsp-70 were found in the exposed cells as compared with the sham-exposed cells. The effects can be considered to be athermal. In the heat control experiments the cells had to be heated up to 3-5°C higher, or for much longer time, to get the same maximum responses as were induced by the microwave irradiation. There was no significant response in the case of Hsp-27.

研究の種別:

研究助成

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