研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒトリンパ球でのクロマチン転座へのGSMマイクロ波の非熱的影響と熱ショックの類似性] med./bio.

Nonthermal GSM Microwaves Affect Chromatin Conformation in Human Lymphocytes Similar to Heat Shock.

掲載誌: IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc 2004; 32 (4): 1600-1608

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研究目的(著者による)

To study whether microwaves of Global System for Mobile Communication (GSM) induce changes in chromatin conformation in human lymphocytes.

詳細情報

Heat treatment (40-46°C) and treatment with the genotoxic agent camptothecin were used as positive controls.
Immortal lymphoblastoid (transformed) cell line was obtained by infection of human lymphocytes of healthy donor with EBV.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 895–915 MHz
Modulation type: pulsed
ばく露時間: continuous for 30 min or 1 h
  • 電力: 2 W cf. remarks (in pulse)
  • SAR: 5.4 mW/kg mean

ばく露1

主たる特性
周波数 895–915 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 30 min or 1 h
Additional information The test mobile phone was programmed to use pre-set frequencies of 895, 900, 905, 910, and 915 MHz.
Modulation
Modulation type pulsed
Pulse width 577 µs
Duty cycle 12.5 %
Additional information

Standard GSM modulation with waiting time of 4039 µs (seven time slots) between pulses. Voice modulation was not applied, and discontinuous transmission mode (DTX) was off.

ばく露装置
ばく露の発生源/構造
チャンバの詳細 output of the phone connected by coaxial cable to the TEM cell
ばく露装置の詳細 all exposures were performed at room temperature in 5-ml round-bottom tubes with 0.5 ml of cell suspension per tube
Sham exposure A sham exposure was conducted.
Additional information because no significant differences were observed between control and sham-exposed cells, the data from both were pooled to compare with the effects of EMF
パラメータ
測定量 種別 Method Mass 備考
電力 2 W cf. remarks 測定値 - in pulse
SAR 5.4 mW/kg mean 測定値および計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The findings have shown that microwaves from GSM mobile phone affected chromatin conformation in human normal and transformed lymphocytes. Because of the very low SAR value in the exposed samples, the microwave effects could not be attributed to heating induced by the exposure system. The exposure level in this study was far below the ICNIRP value.
GSM microwaves under specific conditions of exposure affected human lymphocytes similar to stress response. The findings indicated that the microwave effects differ at various GSM frequencies and vary between donors.

研究の種別:

研究助成

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