この研究は、ピクロトキシンで前処理されたラットに、GSM携帯電話電磁界またはこれと等量の無変調の電磁界のばく露を与え、臨床的徴候および脳電図（EEG）上の徴候、さらには脳におけるc-Fos発現を調べた。その結果、GSM電磁界ばく露による影響は、無変調の電磁界ばく露によるものと違いが見られた；どちらの電磁界ばく露も生体組織の加熱を引き起こさなかったので、熱の影響は除外された；ピクロトキシン処理ラットのc-Fos発現に対するGSM電磁界ばく露の最も顕著な影響は、辺縁系構造、嗅覚皮質領域と皮質下領域、歯状回、視床の層内核グループの中心外側核で観察された；ピクロトキシンの前処理なしのラットが無変調電磁界ばく露を受けた場合、皮質領域で最高レベルのニューロンc-Fos発現が見られた；これらの知見は、ピクロトキシン誘発発作傾向ラットモデルの脳活動に対して、GSMパルス変調電磁界が特定の効果を持つ可能性を示唆している、と報告している。
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To assess whether the effects on brain activity of pulse modulated GSM differ from those of a non-modulated signal of the same wavelength and if so to study c-Fos expression in seizure-related [induced by picrotoxin] anatomical circuits.
Male rats were assigned to six groups: 1) injection with picrotoxin [induced seizure-proneness]/no exposure; 2) injection with picrotoxin/exposure to 900 MHz pulse modulated GSM; 3) injection with picrotoxin/exposure to 900 MHz un-modulated signal; 4) no exposure/no picrotoxin; 5) GSM exposure only; and 6) un-modulated signal only.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
900 MHz
Modulation type:
CW
ばく露時間:
continuous for 2 hr
|
|
|
ばく露2:
900 MHz
ばく露時間:
continuous for 2 hr
|
rats were assigned to one of the following groups: i) injection of picrotoxin (PT) ii) injection of PT+ pulse-modulated EMF iii) injection of PT + unmodulated EMF iv) no injection of PT + no EMF exposure v) no injection of PT + pulse-modulated EMF vi) no injection of PT + unmodulated EMF
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 2 hr |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 |
|
|---|---|
| ばく露装置の詳細 | rats placed in 150 cm x 46 cm x 70 cm radiation cage incorporating a commercial transmitting antenna |
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 2 hr |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
| ばく露の発生源／構造 |
|
|---|
Picrotoxin-treated rats showed no significant EEG abnormalities and all brain areas showed c-Fos expression, with or without posterior exposure (group 1-3). GSM-exposed picrotoxin-pretreated rats (group 2) showed differences in EEG-signs, and in c-Fos expression in the brain, with respect to picrotoxin-treated rats exposed to an equivalent dose of un-modulated exposure (group 3). In group 2, GSM-exposure induced seizures and increased c-Fos-positive neuron counts and the most marked effects were observed in limbic structures, piriform cortex areas and subcortical areas.
Non-picrotoxin-treated animals exposed to un-modulated radiation (group 6) showed the highest levels of neuronal c-Fos expression in cortical areas compared to GSM-exposure (group 5) or no exposure (group 4).
For un-modulated signals (group 3 and 6) occasional discharges occured in EEG recording and seizure development was infrequent in picrotoxin-treated animals (group 3). There was no significant difference in c-Fos expression between non-picrotoxin-treated rats (group 6) and picrotoxin-treated rats (group 3) for un-modulated signals.
900 MHz GSM exposure increased the neuronal excitability in picrotoxin-treated rats, as manifested by behavioral indicators (seizures), EEG indicators, and neuronal c-Fos expression, with respect to rats exposed to unmodulated exposure.
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