研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話電磁界によりマウスの胚に生じた頭蓋骨及び頭蓋後部の骨の変異] med./bio.

Cranial and postcranial skeletal variations induced in mouse embryos by mobile phone radiation.

掲載誌: Pathophysiology 2010; 17 (3): 169-177

この実験研究は、妊娠5日前から出産までの間、マウスに通常の携帯電話会話モードで発生する電磁界(ケージでの電界強度実測値は30±5 V/m)を与えた。ばく露群は、1日当たり6分間の群(7匹)と30分間の群(7匹)であり、擬似ばく露した対照群は5匹である。出産した同腹の仔の一部は歯芽萌出時期まで母マウスの共に過ごさせたが、その他の出生仔(対照群7匹、6分間ばく露群20匹、30分間ばく露群20匹)はパラフィン固定して軟組織および骨格異常を調べた。その結果、ばく露群は対照群に比べ、頭蓋骨と肋骨の骨化における変化やメッケル軟骨の変位が見られたこと、歯牙萌出後に調べた同腹の仔は正常な表現型を示したことから、ばく露による軽微で一時的な骨化への影響の可能性を報告している。

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研究目的(著者による)

To study the embryonic development of mice whose dams were exposed to mild radiofrequency electromagnetic fields emitted by a mobile phone.

詳細情報

Dams were exposed five days before mating. Additionally, pregnant mice were exposed to GSM 900 MHz from the beginning of the pregnancy (total exposure time during pregnancy: 1) 5 mice for 0 min, 2) 7 mice for 126 min (6 min/day) and 3) 7 mice for 630 min (30 min/day)). 7 newborns of group 1, 20 newborns of group 2 and 20 newborns of group 3 were investigated: Within 5 h after birth most newborns were investigated. Other newborns (5 of group 1, 7 of group 2 and 7 of group 3) remained with their mothers until teeth eruption before further investigation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 6 min/day or 30 min/day during 5 days before and during the whole pregnancy
  • 電界強度: 30 V/m (+/- 5 V/m inside the cages)
  • SAR: 0.6 W/kg minimum (inside the cages)
  • SAR: 0.94 W/kg maximum (inside the cages)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 6 min/day or 30 min/day during 5 days before and during the whole pregnancy
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
ばく露装置の詳細 9 cm x 19 cm x 12 cm cages; commercially available GSM mobile phone placed in the middle of the cage's base under a sheet of dielectric material
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 30 V/m - 測定値 - +/- 5 V/m inside the cages
SAR 0.6 W/kg minimum 計算値 - inside the cages
SAR 0.94 W/kg maximum 計算値 - inside the cages

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Radiofrequency electromagnetic field exposed newborn mice, externally examined, displayed a normal phenotype. However, histochemical and histological investigations revealed variations in the exposed foetuses with respect to the controls concerning the ossification of cranial bones and thoracic cage ribs, as well as displacement of Meckelian cartilage. Littermates examined after teeth eruption displayed normal phenotypes with normal osteogenic pattern.
The authors conclude that mild exposure to mobile phone irradiation may affect, although transiently, mouse foetal development at the ossification level.

研究の種別:

研究助成

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