研究のタイプ: 医学/生物学の研究 (experimental study)

[1800MHz電磁放射が誘導するラット皮質ニューロン損傷に対する緑茶ポリフェノールの保護能力] med./bio.

Potential protection of green tea polyphenols against 1800 MHz electromagnetic radiation-induced injury on rat cortical neurons.

掲載誌: Neurotox Res 2011; 20 (3): 270-276

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研究目的(著者による)

To study the possible protective effects of green tea polyphenols against electromagnetic irradiation-induced injury in the cultured rat cortical neurons.

詳細情報

After exposure, the cells were treated with green tea polyphenols for 4 h (different concentrations). Green tea polyphenols have been shown to have a antioxidant capacity, anti-proliferative ability, and anti-carcinogenic properties in neurodegenerative diseases.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
ばく露時間: continuous for 6 x 2 h/day on 2 days
  • 電界強度: 28.67 V/m minimum (+/- 0.88 V/m in the cell culture plates)
  • 電界強度: 92.67 V/m minimum (+/- 1.2 V/m in the cell culture plates)

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 6 x 2 h/day on 2 days
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • Nokia 6060v
チャンバの詳細 incubator with a constant temperature of 37°C, 95% air and 5% CO2
ばく露装置の詳細 mobile phone placed above the cell culture plates with the antenna positioned over their center
Sham exposure A sham exposure was conducted.
Additional information for sham exposure the mobile phone was in stand-by mode
パラメータ
測定量 種別 Method Mass 備考
電界強度 28.67 V/m minimum - - +/- 0.88 V/m in the cell culture plates
電界強度 92.67 V/m minimum - - +/- 1.2 V/m in the cell culture plates

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that the mobile phone exposure for 24 h induced marked neuronal cell death in the TUNEL assay and a decreased cell viability in the MTT assay. Protective effects of green tea polyphenols (10 µM) on the injured cortical neurons were demonstrated by testing the content of Bax. The mobile phone irradiation-induced increases in the content of active Bax were inhibited significantly by green tea polyphenols, while the contents of total Bax had no marked changes after the treatment of green tea polyphenols. The mobile phone exposure increased the protein expression of Hsp70 compared with the sham exposed control.
The results suggest a neuroprotective effect of green tea polyphenols against the mobile phone irradiation-induced injury in the cultured rat cortical neurons.

研究の種別:

研究助成

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