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To study the possible protective effects of green tea polyphenols against electromagnetic irradiation-induced injury in the cultured rat cortical neurons.
After exposure, the cells were treated with green tea polyphenols for 4 h (different concentrations). Green tea polyphenols have been shown to have a antioxidant capacity, anti-proliferative ability, and anti-carcinogenic properties in neurodegenerative diseases.
|ばく露時間||continuous for 6 x 2 h/day on 2 days|
|チャンバの詳細||incubator with a constant temperature of 37°C, 95% air and 5% CO2|
|ばく露装置の詳細||mobile phone placed above the cell culture plates with the antenna positioned over their center|
|Sham exposure||A sham exposure was conducted.|
|Additional information||for sham exposure the mobile phone was in stand-by mode|
The data showed that the mobile phone exposure for 24 h induced marked neuronal cell death in the TUNEL assay and a decreased cell viability in the MTT assay. Protective effects of green tea polyphenols (10 µM) on the injured cortical neurons were demonstrated by testing the content of Bax. The mobile phone irradiation-induced increases in the content of active Bax were inhibited significantly by green tea polyphenols, while the contents of total Bax had no marked changes after the treatment of green tea polyphenols. The mobile phone exposure increased the protein expression of Hsp70 compared with the sham exposed control.
The results suggest a neuroprotective effect of green tea polyphenols against the mobile phone irradiation-induced injury in the cultured rat cortical neurons.