研究のタイプ: 医学/生物学の研究 (experimental study)

[緑茶カテキンはマイクロ波による心臓組織の酸化的損傷からラットを保護する] med./bio.

Green tea catechins protect rats from microwave-induced oxidative damage to heart tissue.

掲載誌: J Med Food 2004; 7 (3): 299-304

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研究目的(著者による)

To study the effects of green tea catechins (antioxidants) on oxidative damage in the heart tissue of microwave exposed rats.

詳細情報

The exposed rats received one of three diets: 1) catechin-free, 2) 0.25% catechin, or 3) 0.5% catechin. Each group consisted of ten rats. Rats were sacrificed 6 days after microwave irradiation

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: continuous for 15 min.
  • 電力密度: 40 mW/cm² (at a distance of 35 cm)
  • SAR: 9.2 W/kg average over mass (whole body)

General information

Microwave exposed animals were divided into three groups: i) catechin-free diet ii) 0.25 % catechin dietary supplement iii) 0.5 % catechin dietary supplement

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • modified household microwave oven
パラメータ
測定量 種別 Method Mass 備考
電力密度 40 mW/cm² - 測定値 - at a distance of 35 cm
SAR 9.2 W/kg average over mass 測定値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Cytochrome P450 levels in the catechin-free microwave exposed group were increased by 85% compared with the control group. However, they were 11% and 14% lower in the "microwave + 0.25 % catechin" and "microwave + 0.5 % catechin" groups than in the catechin-free group.
NADPH-cytochrome P450 reductase enzyme activity in the catechin free group was increased by 29%, compared to the control group, but it was significantly less in the "microwave + 0.25 % catechin" and "microwave + 0.5 % catechin" groups.
Superoxide dismutase activity in the catechin-free group was decreased by 34%, compared with the normal group, but in the "microwave + 0.25 % catechin" and "microwave + 0.5 % catechin" groups it was 19% and 25% higher compared to the catechin-free group. The enzyme activity of glutathione peroxidase in the catechin-free microwave exposed group was decreased by 28% but remained near normal value with catechin supplements.
Superoxide radical concentration in the catechin-free microwave exposed group was increased by 35% compared with the control group. However, superoxide radicals in the "microwave + 0.25 % catechin" and "microwave + 0.5 % catechin" groups were 11% and 12% lower, respectively, compared with the catechin-free group.
Microwave exposure significantly increased levels of thiobarbituric acid-reactive substances, carbonyl group values, and lipofuscin contents, but catechins partially overcame the effects of the microwave irradiation.
In conclusion, oxidative damage was induced by microwave exposure. However, green tea catechin supplementation significantly reduced oxidative damage by weakening the free radical generating system, and strengthening of the antioxidative system.

研究の種別:

研究助成

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