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To study whether prolonged exposure to 900 MHz GSM modulated electromagnetic fields affects viability and vulnerability of two neural cell cultures: primary cortical neurons (primary culture) and SN56 cell line, co-exposed to 25-35AA beta-amyloid (as in vitro model for Alzheimer disease), to glutamate (as model for excitotoxicity) and to H2O2 (as model for oxidative stress).
The two cell cultures were exposed/co-exposed at different time points (after seeding) and for different durations.
Modulation type: pulsed
ばく露時間: up to 144 h
|ばく露時間||up to 144 h|
|Repetition frequency||217 Hz|
|ばく露装置の詳細||thin inner conductor in the TEM cell provided two symmetrical large regions with field homogeneity; TEM cell placed inside an incubator|
|Sham exposure||A sham exposure was conducted.|
The data showed that radiofrequency exposure did not change cell viability and proliferation rate of the SN56 cholinergic cells or viability of cortical neurons. Co-exposure to radiofrequency exacerbated neurotoxic effect of hydrogen peroxide in SN56 cells, but not in primary cortical neurons, whereas no cooperative effects of radiofrequency exposure with glutamate and 25-35AA beta amyloid were found.
These findings suggest that only under particular circumstances exposure to GSM modulated, 900 MHz signal act as a co-stressor for oxidative damage of neural cells.