研究のタイプ: 医学/生物学の研究 (experimental study)

[アミノ酸の水和過程に対する磁界の影響:L-フェニルアラニンおよびL-グルタミンの振動分光研究] med./bio.

Influence of magnetic fields on the hydration process of amino acids: Vibrational spectroscopy study of L-phenylalanine and L-glutamine.

掲載誌: Bioelectromagnetics 2014; 35 (2): 129-135

この研究は、水溶液中のL-フェニルアラニン(L-Phe)およびL-グルタミン(L-Gln)の構造に対する弱い電磁界の影響を、減衰全反射フーリエ変換赤外(ATR-FTIR)分光法を用いて調べた。適用した磁界は、DCまたは50-100 Hz、強度は50μTまたは150μTで、実験室での地磁気(45μT)の方向に垂直とした。その結果、短時間のDCまたは50 Hzばく露により、試料の分光スペクトラムに変化が起きた、などを報告している。

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研究目的(著者による)

To study the effect of weak magnetic fields on the structure of the amino acids L-glutamine and L-phenylalanine in aqueous solution.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 30 min
ばく露2:
  • DC/static
ばく露時間: continuous for 30 min
ばく露3: 50 Hz
ばく露時間: continuous for 30 min
ばく露4:
  • DC/static
ばく露時間: continuous for 30 min

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 30 min
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 Helmholtz coils with a radius of 2.5 cm and equal spacing (oriented vertically in order to produce a horizontal field almost perpendicular to the geomagnetic field); samples were placed in the space between the coils; temperature between the coils was coincident with the room temperature of 21±1°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 50 µT maximum - - -

ばく露2

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 continuous for 30 min
ばく露装置
ばく露の発生源/構造
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 50 µT maximum - - -

ばく露3

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 30 min
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 single coil with a radius of 2.5 cm; temperature between the coils was coincident with the room temperature of 21±1°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 150 µT maximum - - -

ばく露4

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 continuous for 30 min
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 single coil with a radius of 2.5 cm; temperature between the coils was coincident with the room temperature of 21±1°C
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 150 µT maximum - - -

Reference articles

  • De Ninno A et al. (2011): [弱い磁界が誘導するグルタミン酸の脱プロトン化:フーリエ変換型赤外分光‐減衰全反射法(FTIR-ATR)研究]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Exposure to a direct current field or a 50 Hz alternating field field for a short time induced modifications in the spectra of exposed samples in agreement with previous observations on glutamic acid (De Ninno and Castellano 2011a). Furthermore, in the case of L-phenylalanine, the exposure induced a measurable shift of acid dissociation constant, while in case of L-glutamine, the effect is under the limit detectable with this method.
The authors suggest that the magnetic field modifies the water structure around the molecules and changes the hydrophobic interactions allowing the molecules of amino acids to aggregate. The differences observed in the behavior of L-phenylalanine and L-glutamine may be related to the differences in the polarity of their residues.

研究の種別:

研究助成

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