研究のタイプ: 疫学研究 (observational study)

[超低周波電磁界への居住環境ばく露とALSのリスク。] epidem.

Residential exposure to extremely low frequency electromagnetic fields and the risk of ALS.

掲載誌: Neurology 2014; 83 (19): 1767-1769

この研究は、筋萎縮性側索硬化症(ALS)の表現型などの詳細な臨床データを用いて、送電線からの超低周波電磁界(ELF-MF)への居住環境ばく露とALSのリスクの関連を調べた人口ベースの大規模症例対照研究である。公衆にとって重要なELF-MF発生源である送電線の近傍居住とALSリスクの関連を調べた先行研究は3件あり、リスク上昇が見られないことを報告しているが、登録ベースの研究のため臨床データを利用できなかったという短所があった。

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研究の目的(著者による)

A population-based case-control study was conducted in the Netherlands to investigate the association between residential exposure to extremely low frequency magnetic fields from power lines and the risk of amyotrophic lateral sclerosis (ALS).

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (オッズ比(OR))

ばく露

ばく露評価

ばく露集団

グループ 説明
集団 1 distance between residence and power line (220-380 kV): 0 - < 50 m
集団 2 distance between residence and power line (220-380 kV): 50 - < 200 m
集団 3 distance between residence and power line (220-380 kV): 200 - < 600 m
参照集団 4 distance between residence and power line (220-380 kV): ≥ 600 m
集団 5 distance between residence and power line (50-150 kV): 0 - < 50 m
集団 6 distance between residence and power line (50-150 kV): 50 - < 200 m
集団 7 distance between residence and power line (50-150 kV): 200 - < 600 m
参照集団 8 distance between residence and power line (50-150 kV): ≥ 600 m

調査対象集団

症例集団

対照集団

調査規模

症例 対照
適格者 1,139 2,864
統計学的分析方法: (調整: )

結論(著者による)

Six cases and 14 controls have been living at a distance up to 50 m to a high voltage power line of 50-150 kV, no case and only one control have been living at the same distance to a power line of 220 kV and 380 kV.
No increased risk of amyotrophic lateral sclerosis was observed in persons living in close vicinity of a power line compared to persons who had always lived at a distance of at least 600 meters. Cumulative exposure showed no dose-response relationship. Survival analysis in patients with amyotrophic lateral sclerosis showed a nonsignificant hazard ratio of 1.27 (CI 0.87-1.86). No association between distance from a power line and age at onset was found (HR 1.22, CI 0.89-1.67).
The authors conclude that exposure to extremely low frequency magnetic fields from power lines does not increase the risk of developing amyotrophic lateral sclerosis.

研究の限界(著者による)

Only a few participants have been living in close vicinity to power lines (< 200 m).

研究助成

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