研究のタイプ: 医学／生物学の研究 (experimental study)

[卵巣の原始卵胞の数に対する電磁界の影響：実験的研究] med./bio.

The effects of electromagnetic fields on the number of ovarian primordial follicles: An experimental study

著者: Bakacak M, Bostanci MS, Attar R, Yildirim OK, Yildirim G, Bakacak Z, Sayar H, Han A
掲載誌: Kaohsiung J Med Sci 2015; 31 (6): 287-292
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この研究は、ラットの卵巣の原始卵胞の数に対する電磁界の影響を実験的に調べた。4月齢雌ラット（n=16）をばく露群、対照群（各8匹）に分けた。ばく露の方法は、麻酔されたラットを実験者が手で保持し、900MHz放射アンテナを腹部皮膚に直接当てて行った（1日15分間、15日間）。対照群も、放射の無いアンテナを用いて同じ処置を行った。ばく離終了後、卵巣を摘出して組織学的検査を実施した。その結果としてばく露群での卵巣卵胞の数の低下が観察されたと報告している。

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研究目的（著者による）

The effects of an abdominal exposure of rats to a 900 MHz electromagnetic field on the number of primordial follicles in the ovaries should be investigated.

詳細情報

Primordial follicles represent the primary state of ovarian follicles. They consist of an ovum and a layer of flattened epithelial cells.
Rats were randomly divided into two groups (n=8 each): 1) exposure to the electromagnetic field and 2) sham exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 minutes/day for 15 days
  • 電力: 5 W peak (output power)
  • 電力密度: 1.04 mW/cm²
  • SAR: 0.018 W/kg minimum (whole body)
  • SAR: 4 W/kg maximum (whole body)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 minutes/day for 15 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • exposure device with a special antenna
チャンバの詳細 radio frequency-shielded room
ばく露装置の詳細 the researcher's left hand grasped the rat at the neck and back and the right hand applied the antenna device to the skin of the rat over the ovaries in the lower abdominal area; ambient temperature of 22-26°C and 55-60% humidity
Sham exposure A sham exposure was conducted.
Additional information rats of the sham exposure group were taken from their cages and treated with the antenna in the same manner as rats in the experimental group, but the exposure device was turned off
パラメータ
測定量 値 種別 Method Mass 備考
電力 5 W peak - - output power
電力密度 1.04 mW/cm² - 測定値 - -
SAR 0.018 W/kg minimum 測定値 whole body -
SAR 4 W/kg maximum 測定値 whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム（著者による）

No significant differences were found in the body weight and weight of ovaries between exposed and sham exposed rats.
The mean numbers of primordial follicles in the ovaries were significantly lower in exposed rats compared to sham exposed rats.
The authors conclude that an abdominal exposure of rats to a 900 MHz electromagnetic field could reduce the number of primordial follicles in the ovaries.

研究の種別:

研究助成

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