研究のタイプ: 医学/生物学の研究 (experimental study)

[健康な小児期および思春期層における頻繁な携帯電話使用はメンタルストレス後の携帯電話通話への視床下部-下垂体-副腎系反応を変化させる:パイロット研究] med./bio.

Frequent cellular phone use modifies hypothalamic-pituitary-adrenal axis response to a cellular phone call after mental stress in healthy children and adolescents: A pilot study.

掲載誌: Sci Total Environ 2015; 536: 182-188

この研究は、調査参加者の健康な学齢期の小児(11-14歳)を携帯電話の使用頻度により2群(A群:時々の使用者、B群:規則的使用者)に分け、12時間の断食後の朝8時に採血し、甲状腺ホルモングルコースインスリンコルチゾールのレベルを測定した。コルチゾール測定のための唾液試料を、ベースライン時、メンタルストレス負荷から10および20分後、および携帯電話通話(5分間)の10および20分後にそれぞれ採取した。メンタルストレス負荷には、小児用の社会的ストレステスト(TSST-C:5分間のスピーチタスクと5分間の暗算タスク)を用いた。その結果、携帯電話通話の10分後と20分後の唾液コルチゾールレベルに有意差が見られ、その反応はA、B群で異なっていた;ベースラインの甲状腺ホルモンレベルは、主にA群におけるメンタルストレス唾液コルチゾール反応の予測因子であったが、HOMA(インスリン抵抗性の指標)はどちらの群の唾液コルチゾール反応にも影響しなかった、と報告している。

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研究目的(著者による)

The effects of mental stress and acute exposure to a mobile phone on the salivary cortisol levels of children, which were categorized according to the extent of their everyday mobile phone usage, should be investigated.

詳細情報

Cortisol is the final hormone of the hypothalamic-pituitary-adrenal axis and was therefore used as a marker.
28 children aged 11-14 were divided into 2 groups: 1) those who did not possess or occasionally used a mobile phone (n = 16) and 2) those who possessed and regularly used a mobile phone (n=12). All subjects participated in one session, comprising of an initial blood sample donation followed by a mental stress provocation (Trier Social Stress Test) and a final 5 minute mobile phone call. Between each block, there was an intermediate resting interval and during these intervals, a total of 5 saliva samples were taken: before the stress test (baseline value), 10 minutes after the stress test, 20 minutes after the stress test, 10 minutes after the use of the mobile phone and 20 minutes after the use of the mobile phone.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: continuous for 5 minutes
occassional users
  • SAR: 0.268 W/kg minimum
  • SAR: 102 W/kg maximum (probably 1.02 W/kg)
ばく露2:
ばく露時間: continuous for 5 minutes
regular users
  • SAR: 0.57 W/kg minimum (specifications not clear)
  • SAR: 1.02 W/kg maximum (specifications not clear)

ばく露1

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 5 minutes
Additional information occassional users
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • 2G or 3G phones
ばく露装置の詳細 the participants were placed in supine posture on a typical metallic bed with cotton mattress, whose distance from each wall of the room was 0.7 m Œ 0.2 m Œ 3.47 m Œ 0.95 m; a second similar bed and a small metallic table (with experimental instruments) had been also placed in the room; each participant used their personal phone for exposure; the hypothalamus, the pituitary, the thyroid and the salivary glands of the participants were exposed to the near field, whereas the adrenal gland of tall participants might be exposed to the far field of the cellular phone antenna
パラメータ
測定量 種別 Method Mass 備考
SAR 0.268 W/kg minimum 指定なし - -
SAR 102 W/kg maximum 指定なし - probably 1.02 W/kg

ばく露2

主たる特性
周波数
タイプ
  • electromagnetic field
ばく露時間 continuous for 5 minutes
Additional information regular users
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
SAR 0.57 W/kg minimum 指定なし - specifications not clear
SAR 1.02 W/kg maximum 指定なし - specifications not clear

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

The height, weight and BMI were significantly larger in regular mobile phone users (group 2) compared to occasional user (group 1), as participants in group 2 were 2 years older on average.
Baseline salivary cortisol levels were significantly higher in group 2 compared to group 1. In group 2, no changes were observed in the cortisol levels after stress provocation and mobile phone exposure. In group 1, however, the cortisol levels decreased significantly compared to the baseline value in response to stress provocation and mobile phone exposure.
The authors conclude that the salivary cortisol level in children could be influenced by mental stress and acute exposure to a mobile phone depending on the extend of the everyday mobile phone usage.

研究の種別:

研究助成

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