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The effects of exposure of mesenchymal stem cells from rat and mouse to a 50 Hz magnetic field on cell proliferation and cytokine production should be investigated.
Rat and mouse stem cells were divided into two groups, respectively: 1) exposure to the magnetic field and 2) sham exposure (remark EMF-Portal: additional tests were conducted with macrophages, but as they did not investigate the direct effects of exposure to the magnetic field, they are not regarded here).
ばく露時間: continuous for 4 hours/day for up to 7 days
|ばく露時間||continuous for 4 hours/day for up to 7 days|
|チャンバの詳細||petry dishes, well plates and flasks (depending on method)|
|ばく露装置の詳細||two independent electromagnetic field generators connected to a computer via a specific sensor|
|Sham exposure||A sham exposure was conducted.|
The following parameters were significantly increased in exposed rat stem cells compared to the sham exposure group: cell proliferation after 3 to 7 days, DNA synthesis, proportion of cells in S phase in the cell cycle distribution and the gene expression rates of SCF and CSF after 2 and 3 days.
In mouse stem cells, the gene expression rates of SCF, CSF, TPO, LIF, IL-11 and IL-7 were significantly increased in the exposure group compared to the sham exposure group.
The authors conclude that exposure of mesenchymal stem cells from rat and mouse to a 50 Hz magnetic field could stimulate the cell proliferation and the production of some cytokines.