研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの脳、血液、肝臓および腎臓における脂質過酸化に対する電磁界(1800MHz)の影響] med./bio.

Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats.

掲載誌: Int J Occup Med Environ Health 2015; 28 (4): 751-759

この研究は、健康および完全フロイントアジュバント(CFA)誘発による持続性の炎症性疼痛モデルのウィスターラットを用いて、電磁界EMF:1800MHz)の反復ばく露(15分間のばく露を5回)の単独および鎮痛剤との組み合わせが、組織脂質過酸化(LPO)に与える影響を調べた。LPOの最終産物であるマロンジアルデヒドMDA)濃度を脳、血液肝臓および腎臓組織で測定した。その結果、健康および炎症性疼痛モデルのどちらのラットでも、鎮痛剤と組み合わせた反復的EMFばく露群において、脳、血液腎臓脂質過酸化の若干の増強が見られた、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

The effects of exposure of rats to a 1800 MHz electromagnetic field on lipid peroxidation in brain, blood, liver and kidney.

詳細情報

Experiments were conducted on healthy rats and rats with an experimentally induced inflammation (injection of Complete Freund's Adjuvant into paw), together with or without the opioid tramadol as co-exposure. Possible relations of these factors to an electromagnetic field were observed in a former study (Bodera et al. 2013).
Rats were divided into the following groups (n=8 each):
Healthy rats: 1) exposure to the electromagnetic field and intraperitoneal sham injection (water), 2) sham exposure and injection of 20 mg/kg tramadol prior to exposure, 3) exposure and injection of tramadol, 4) sham exposure and sham injection (control group for healthy rats).
Rats with inflammation: 5) exposure and sham injection, 6) sham exposure and injection of tramadol, 7) exposure and injection of tramadol, 8) sham exposure and sham injection (control groups for rats with inflammation).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 minutes/day for 5 days
  • SAR: 0.024 W/kg minimum
  • SAR: 0.028 W/kg maximum
  • 磁界強度: 0.05 A/m effective value
  • 電界強度: 20 V/m effective value (1.3 m away from the antenna (in the center of exposure container))

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 15 minutes/day for 5 days
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Duty cycle 50 %
Repetition frequency 877 Hz
Additional information

the fundamental unit of time in this TDMA scheme (a burst period) lasts for 15/26 ms (approximately 0.577 ms); eight burst periods are grouped into a TDMA frame (120/26 ms or approximately 4.615 ms), which forms the basic unit of a logical channel

ばく露装置
ばく露の発生源/構造
チャンバの詳細 plexiglass containers (218 mm length and width, 134 mm height, wall thickness 5 mm); each rat occupied 1/2 of the space of the container, separated by a transparent plastic wall (5 mm in thickness) and could not move inside this space (? SAR calculated for different positions)
ばく露装置の詳細 animals were placed in pairs in plexiglass containers in 1 m (or 1.2 m?) distance to the antenna; the propagation vector of the incident wave was parallel to the long axis of the animal's body
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.024 W/kg minimum 計算値 - -
SAR 0.028 W/kg maximum 計算値 - -
磁界強度 0.05 A/m effective value - - -
電界強度 20 V/m effective value 測定値 - 1.3 m away from the antenna (in the center of exposure container)

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In both, healthy rats and rats with inflammation, exposure to the electromagnetic field (groups 1 and 5) resulted in significantly increased lipid peroxidation in the blood and in the brain compared to the respective control groups (groups 4 and 8). In groups with a combination of exposure to the electromagnetic field and tramadol (groups 3 and 7), a significant increase of lipid peroxidation in the blood, in the brain and in the kidneys in comparison to the control group was observed.
A treatment of healthy rats with tramadol alone (group 2) led to significant increases of lipid peroxidation in the blood, in the brain and in the kidneys compared to the respective control group, whereas a tramadol treatment of rats with inflammation resulted in a significant increase of lipid peroxidation in the kidneys and a significant reduction in the blood.
In the liver, no significant differences were found between the groups. Moreover, no significant differences were found between healthy rats and rats with inflammation with the same treatment.
The authors conclude that exposure of rats to a 1800 MHz electromagnetic field might increase lipid peroxidation in brain, blood and kidneys and that co-exposure to tramadol could show a synergistic effect.

研究の種別:

研究助成

関連論文