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To investigate the possible effects of exposure to 50 Hz magnetic fields during early pregnancy on the number and quality of mice blastocysts.
In total, 66 mice were divided into an exposure and a control group (n=33, respectively). Blastocysts were obtained by flushing the uterine horn and fallopian tubes on day three of gestation.
ばく露時間: continuously for 48 hours
|ばく露時間||continuously for 48 hours|
|ばく露装置の詳細||exposure system consisted of a power supply with a permanent current intensity of 3 A, 220 V input and 5 V output voltage, a multi-meter to control the intensity of the current and the magnetic field generating device; the Helmholtz coil with 380 turns wound around a cylinder (diameter 19 cm, length 15.5 cm) contained a chamber to house the mice in the center of the cylinder; temperature was 37°C ± 0.1°C|
|磁束密度||6 mT||-||測定値||-||± 0.1 mT|
No significant difference was found in the number of blastocysts between the exposure and the control group. However, the number of total cells, trophoblast cells, and embryoblast cells were significantly reduced in blastocysts from exposed animals compared to those derived from the control group while the ratio of embryoblast cells to trophoblast cells was significantly increased.
The authors conclude that 50 Hz magnetic field exposure could affect the cellular composition of blastocysts in pregnant mice and could hence influence the fertility of female mice.