研究のタイプ: 医学/生物学の研究 (experimental study)

Effects of prenatal exposure to extremely low electro - magnetic field on in vivo derived blastocysts of mice. med./bio.

掲載誌: Int J Reprod Biomed (Yazd) 2012; 10 (6): 555-560

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研究目的(著者による)

To investigate the possible effects of exposure to 50 Hz magnetic fields during early pregnancy on the number and quality of mice blastocysts.

詳細情報

In total, 66 mice were divided into an exposure and a control group (n=33, respectively). Blastocysts were obtained by flushing the uterine horn and fallopian tubes on day three of gestation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuously for 48 hours

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuously for 48 hours
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 exposure system consisted of a power supply with a permanent current intensity of 3 A, 220 V input and 5 V output voltage, a multi-meter to control the intensity of the current and the magnetic field generating device; the Helmholtz coil with 380 turns wound around a cylinder (diameter 19 cm, length 15.5 cm) contained a chamber to house the mice in the center of the cylinder; temperature was 37°C ± 0.1°C
パラメータ
測定量 種別 Method Mass 備考
磁束密度 6 mT - 測定値 - ± 0.1 mT

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした臓器系:
  • blastocysts
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant difference was found in the number of blastocysts between the exposure and the control group. However, the number of total cells, trophoblast cells, and embryoblast cells were significantly reduced in blastocysts from exposed animals compared to those derived from the control group while the ratio of embryoblast cells to trophoblast cells was significantly increased.
The authors conclude that 50 Hz magnetic field exposure could affect the cellular composition of blastocysts in pregnant mice and could hence influence the fertility of female mice.

研究の種別:

研究助成

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